{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:10:01Z","timestamp":1777947001986,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,1,20]],"date-time":"2009-01-20T00:00:00Z","timestamp":1232409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,1,20]],"date-time":"2009-01-20T00:00:00Z","timestamp":1232409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"abstract":"<jats:p>The effect of oxitropium bromide on lung mucociliary clearance, pulmonary function and viscoelastic properties of sputum was investigated in 10 asthmatics and 10 chronic bronchitics. A controlled, double-blind, crossover study was performed. Following a baseline (B) measurement the patients were, in a random order, allocated placebo (P) or oxitropium bromide (O; 0.1 mg\/puff), administered from metered dose inhalers, which they used for 4 weeks at a dose of 2 puffs t.d.s. This test medication was used in conjunction with their normal medication. At the end of the treatment period the patients were assessed, the treatments were then crossed over and a final assessment made 4 weeks later. The administration of oxitropium bromide resulted in (1) small but statistically significant increases in pulmonary function ( &lt; 10% vs. placebo); (2) increased penetrance of radioaerosol into the lungs (mean \u00b1 SEM alveolar deposition: 35 \u00b1 3, 26 \u00b1 3 and 24 \u00b1 3 % for the O, P and B runs respectively; p &lt; 0.025); (3) no significant change in particle clearance rate from the lungs despite their deeper penetration (mean \u00b1 SEM area under the tracheobronchial clearance curves between 0 and 6 h: 317 \u00b1 26, 324 \u00b1 25 and 287 \u00b1 25 % \u00b7 h for the O, P and B runs respectively; p &gt; 0.1); (4) no alteration in sputum production, and (5) no significant changes in apparent viscosity (mean \u00b1 SEM: 640 \u00b1 162, 446 \u00b1 79 and 557 \u00b1 115 mPa \u00b7 s for the O, P and B runs, respectively; p &gt; 0.1) and elasticity (mean \u00b1 SEM: 3,682 \u00b1 1,383, 1,779 \u00b1 353 and 2,061 \u00b1 366 mPa for the O, P and B runs, respectively; p &gt; 0.1) of sputum. When the two groups, i.e. the chronic bronchitics and asthmatics, were studied separately, no significant differences in any parameter measured (other than radioaerosol penetrance which was significantly enhanced on oxitropium bromide in chronic bronchitics) were noted between the three assessments<\/jats:p>","DOI":"10.1159\/000195703","type":"journal-article","created":{"date-parts":[[2009,1,20]],"date-time":"2009-01-20T03:53:22Z","timestamp":1232423602000},"page":"33-43","source":"Crossref","is-referenced-by-count":11,"title":["Effect of Four-Week Treatment with Oxitropium Bromide on Lung Mucociliary Clearance in Patients with Chronic Bronchitis or Asthma"],"prefix":"10.1159","author":[{"given":"D.","family":"Pavia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.T.","family":"Lopez-Vidriero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.E.","family":"Agnew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.G.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Eyre-Brook","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.A.","family":"Lawton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.G.D.","family":"Pellow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.W.","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,1,20]]},"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/195703","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000195703","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T21:23:02Z","timestamp":1777756982000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000195703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,20]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000195703","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,20]]}}}