{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:10:07Z","timestamp":1777947007057,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,1,20]],"date-time":"2009-01-20T00:00:00Z","timestamp":1232409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,1,20]],"date-time":"2009-01-20T00:00:00Z","timestamp":1232409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"abstract":"<jats:p>Leukotriene B&lt;sub&gt;4&lt;\/sub&gt; (LTB&lt;sub&gt;4&lt;\/sub&gt;) is a potent chemotactic factor for polymorphonuclear leukocytes. It was reported recently that pulmonary macrophages from some mammalian species synthesize and release LTB&lt;sub&gt;4&lt;\/sub&gt;. Laviolette et al. reported the decrease of LTB&lt;sub&gt;4&lt;\/sub&gt; synthesis in smokers\u2019 alveolar macrophages (AM). In this paper, we report the chronic effects of passive smoking on the production of LTB&lt;sub&gt;4&lt;\/sub&gt; by rat AM. Some rats inhaled tobacco smoke and some inhaled smoke which did not contain nicotine. LTB&lt;sub&gt;4&lt;\/sub&gt; production from AM from these rats was compared. In the tobacco-smoking group (n = 12), LTB&lt;sub&gt;4&lt;\/sub&gt; production was 8.0 \u00b1 2.4 ng\/106 cells. This value was significantly lower than in the nonsmoking (NS) group (n = 12; 16.5 \u00b1 4.5 ng\/106 cells; p &lt; 0.01) and in the non-nicotinized cigarette smoking (NNCS) group (n = 8; 18.5 \u00b1 3.5 ng\/106 cells; p &lt; 0.01). There were no significant differences between the NS and the NNCS group. These data may suggest that chronic inhalation of nicotine in tobacco smoke decreases LTB&lt;sub&gt;4&lt;\/sub&gt; production activity of rat AM. The precise mechanism of decreased synthesis of LTB&lt;sub&gt;4&lt;\/sub&gt; is not clear but it may have some immunological effects on the lung.<\/jats:p>","DOI":"10.1159\/000195801","type":"journal-article","created":{"date-parts":[[2009,1,20]],"date-time":"2009-01-20T03:53:22Z","timestamp":1232423602000},"page":"198-203","source":"Crossref","is-referenced-by-count":7,"title":["Effects of Smoking on the Synthesis of Leukotriene B\n                    <sub>4<\/sub>\n                    by Rat Alveolar Macrophages"],"prefix":"10.1159","author":[{"given":"Yukihiko","family":"Sugiyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Izumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuya","family":"Ohishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Yotsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumimaro","family":"Takaku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,1,20]]},"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/195801","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000195801","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T21:24:25Z","timestamp":1777757065000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000195801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,20]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000195801","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,20]]}}}