{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:10:08Z","timestamp":1777947008638,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,1,20]],"date-time":"2009-01-20T00:00:00Z","timestamp":1232409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,1,20]],"date-time":"2009-01-20T00:00:00Z","timestamp":1232409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"abstract":"<jats:p>In 10 asymptomatic young smokers and 15 non-smokers, total respiratory impedance was determined by means of the forced oscillation technique in a frequency range between 4 and 52 Hz under basal conditions, and after isocapnic hyperventilation with cold air. In non-smokers, cold-air inhalation caused a statistically significant increase in respiratory restistance between 8 and 28 Hz, and post-challenge reactance values decreased at almost all frequencies. In smokers, respiratory resistance increased at almost all frequencies, but most markedly at lower frequencies in the range from 8 to 28 Hz; respiratory resistance decreased with increasing frequency. Respiratory reactance decreased significantly between 8 and 36 Hz. Comparing the smokers and non-smokers, respiratory resistance and reactance were not significantly different under basal conditions. However, after cold-air challenge, respiratory resistance was significantly higher between 8 and 16 Hz, and respiratory reactance significantly lower between 8 and 40 Hz. It is concluded that after cold-air challenge, a broncho-constricting effect extending largely into the small peripheral airways can be demonstrated by impedance measurement in a group of asymptomatic young smokers which is not observed in normal subjects. Therefore, this method is very useful for the early detection of mechanical abnormalities induced by smoke inhalation.<\/jats:p>","DOI":"10.1159\/000195860","type":"journal-article","created":{"date-parts":[[2009,1,21]],"date-time":"2009-01-21T11:06:40Z","timestamp":1232536000000},"page":"299-303","source":"Crossref","is-referenced-by-count":1,"title":["Early Airway Obstruction in Young Asymptomatic Smokers after Cold-Air Challenge"],"prefix":"10.1159","author":[{"given":"M.","family":"Quaedvlieg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.F.M.","family":"Wouters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,1,20]]},"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/195860","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000195860","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T21:25:12Z","timestamp":1777757112000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000195860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,20]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000195860","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,20]]}}}