{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:10:22Z","timestamp":1777947022728,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,1,20]],"date-time":"2009-01-20T00:00:00Z","timestamp":1232409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,1,20]],"date-time":"2009-01-20T00:00:00Z","timestamp":1232409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"abstract":"<jats:p>The respiratory effects of analgesia with nalbuphine were studied in 9 patients after thoracotomy. The pain score was measured by a visual analogue scale. Ventilatory pattern and occlusion pressure (P&lt;sub&gt;0.1&lt;\/sub&gt;) were studied during spontaneous breathing and during CO&lt;sub&gt;2&lt;\/sub&gt; rebreathing, before and 0.5,1, 2.5, 3.5 and 6 h after a 0.3-mg \u00b7 kg-1 dose of intravenous nalbuphine. Compared to baseline values obtained before the injection, nalbuphine produced a decrease in the pain score (p &lt; 0.001) during the 6-hour experiment period. In spontaneous breathing, P&lt;sub&gt;0.1&lt;\/sub&gt; was reduced by 15% in 1 h and remained decreased during 3.5 h (p &lt; 0.05), whilst PaCO&lt;sub&gt;2&lt;\/sub&gt; and ventilation (V&lt;sub&gt;E&lt;\/sub&gt;) remained unchanged. The P&lt;sub&gt;0.1&lt;\/sub&gt; responsiveness to CO&lt;sub&gt;2&lt;\/sub&gt; was decreased from 0.5 to 2.5 h after the nalbuphine injection (p &lt; 0.05), but the V&lt;sub&gt;E&lt;\/sub&gt; responsiveness to CO&lt;sub&gt;2&lt;\/sub&gt; was reduced only after 1 h (p &lt; 0.01). This study shows that, while post-thoracotomy pain was reduced by analgesia, neuromuscular inspiratory drive and chemosensitivity to CO&lt;sub&gt;2&lt;\/sub&gt; were weakened, without any change in spontaneous ventilation. A partial improvement in the thoracopulmonary mechanics induced by the reduction in chest pain could explain the maintenance of ventilatory level in spite of a decreased neuromuscular inspiratory drive.<\/jats:p>","DOI":"10.1159\/000196048","type":"journal-article","created":{"date-parts":[[2009,1,21]],"date-time":"2009-01-21T11:06:40Z","timestamp":1232536000000},"page":"159-163","source":"Crossref","is-referenced-by-count":0,"title":["Nalbuphine Analgesia Preserves Ventilation after Thoracotomy despite a Reduction in Inspiratory Drive"],"prefix":"10.1159","author":[{"given":"Bernard","family":"Hannhart","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gittes","family":"Boulanger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e9rard","family":"Audibert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie Claire","family":"Laxenaire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,1,20]]},"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/196048","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000196048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T21:27:22Z","timestamp":1777757242000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000196048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,20]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000196048","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,20]]}}}