{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T08:44:53Z","timestamp":1786697093908,"version":"build-2736575974"},"reference-count":24,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2009]]},"abstract":"<i>Introduction:<\/i> In this prospective, randomized, and double-blinded study we investigated the efficacy of haloperidol (10 \u03bcg\/kg) and the combination of haloperidol (10 \u03bcg\/kg) with ondansetron (0.1 mg\/kg) for the prophylaxis of postoperative nausea and vomiting (PONV) after ophthalmologic surgery. <i>Methods:<\/i> 60 patients (ASA status 1\u20133) with risk factors for PONV (female, non-smoker, motion sickness or PONV in history, opioids for postoperative analgesia) undergoing retinal or strabismus surgery were included into the study and randomised to the haloperidol group (H-Group) or the haloperidol-ondansetron group (H\/O-Group). 20 min before the end of anaesthesia the study medication was given. Nausea, vomiting, pain scores, and adverse events were assessed postoperatively over 24 h. <i>Results:<\/i> The incidence of PONV was lower for the H\/O-Group (23 vs. 57% for the H-Group). Especially the incidence of vomiting was reduced for the H\/O-Group (7 vs. 27% in the H-Group). No significant differences could be detected regarding adverse events. <i>Conclusion:<\/i> The single use of haloperidol for the prophylaxis of PONV is doubtful. Better results were obtained with the combination therapy of haloperidol with ondansetron, especially for vomiting.<\/jats:p>","DOI":"10.1159\/000196812","type":"journal-article","created":{"date-parts":[[2009,1,31]],"date-time":"2009-01-31T15:30:40Z","timestamp":1233415840000},"page":"205-210","source":"Crossref","is-referenced-by-count":18,"title":["Haloperidol versus Haloperidol plus Ondansetron for the Prophylaxis of Postoperative Nausea and Vomiting after Ophthalmologic Surgery"],"prefix":"10.1159","volume":"83","author":[{"given":"Oguzhan","family":"Dagtekin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Wiese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Wolter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel M.","family":"Hermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Pietruck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Kampe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,1,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007%2FBF03010904"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0952-8180%2805%2980004-2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007%2FBF03018234"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1399-6576.2006.01171.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2FBF03017787"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1080\/17453670710015355"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186\/1476-9255-10-5"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-011-1871-2"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-012-2526-7"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-012-0944-6"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s001340050644"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1399-6576.2000.441011.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007%2FBF03013781"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1213%2F00000539-197211000-00034"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093%2Fbja%2F88.5.659"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007%2FBF03022656"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1017%2FS0265021506001323"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2044.2002.02822.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1213%2Fane.0b013e3181609424"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1213%2Fane.0b013e3181609022"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1213%2Fane.0b013e31816091f0"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1399-6576.2002.460801.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097%2F00000542-200412000-00028"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1213%2F01.ANE.0000105880.59649.5C"}],"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/196812","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/196812","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T23:33:25Z","timestamp":1745451205000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000196812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2009,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000196812","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}