{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:38:48Z","timestamp":1777865928136,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,1,22]],"date-time":"2009-01-22T00:00:00Z","timestamp":1232582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,1,22]],"date-time":"2009-01-22T00:00:00Z","timestamp":1232582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"abstract":"<jats:p>An analysis of the microscopical appearances of the liver in 18 patients dying of fulminant hepatic failure showed distinct differences according to the likely cause and duration of survival. In particular, mitotic figures were observed only in those dying early in the course of the disease and hyperplasia of surviving cells with nodule formation only in those who lived for longer than 10 days. A significant proportion of the cells comprising the mononuclear cell infiltrate were demonstrated to be pyroninophilic. Such cells were present more frequently in those with presumed viral hepatitis than in those with toxic liver damage from paracetamol or halothane and constitute further evidence in favour of the view that immunological processes may play some part in the pathogenesis of the hepatic necrosis.<\/jats:p>","DOI":"10.1159\/000197301","type":"journal-article","created":{"date-parts":[[2009,1,26]],"date-time":"2009-01-26T09:24:49Z","timestamp":1232961889000},"page":"68-79","source":"Crossref","is-referenced-by-count":4,"title":["Histological Appearances in Fulminant Hepatic Failure with Reference to Aetiology, Time of Survival and Role of Immunological Processes"],"prefix":"10.1159","author":[{"given":"J.","family":"Goertz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,1,22]]},"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/197301","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000197301","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T07:42:25Z","timestamp":1777534945000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000197301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,22]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000197301","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,22]]}}}