{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T02:48:38Z","timestamp":1788749318162,"version":"build-2803163510"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,1,23]],"date-time":"2009-01-23T00:00:00Z","timestamp":1232668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,1,23]],"date-time":"2009-01-23T00:00:00Z","timestamp":1232668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"abstract":"<jats:p>The clinical and pathological features of 21 patients with histologically proven hepatic amyloidosis are described. Hepatomegaly, splenomegaly and ascites were commonly found, but the clinical-pathological correlation of these findings was poor. None of the patients had clinical stigmata associated with chronic liver disease. Liver amyloidosis was the cause of death in only one case who had severe cholestatic jaundice. The classi fication of hepatic amyloidosis based on predominantly intralobular or portal amyloid deposition in the liver offers a better correlation between structure and function. Predominantly intralobular involvement was less frequent (24% of the cases), but seemed to be distinct from portal involvement in that it produced massive hepatosplenomegaly and ascites and was more frequently associated with cardiac amyloidosis. In patients with intralobular involvement high serum alkaline phosphatase levels were usually found, and the cases with severe jaundice belong to this group.<\/jats:p>","DOI":"10.1159\/000197521","type":"journal-article","created":{"date-parts":[[2009,1,26]],"date-time":"2009-01-26T09:24:49Z","timestamp":1232961889000},"page":"40-51","source":"Crossref","is-referenced-by-count":27,"title":["The Liver in Amyloidosis"],"prefix":"10.1159","author":[{"given":"M.","family":"Levy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Polliack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Eliakim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,1,23]]},"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/197521","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000197521","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T07:44:24Z","timestamp":1777535064000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000197521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,23]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000197521","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,23]]}}}