{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:49:49Z","timestamp":1745470189081,"version":"3.40.4"},"reference-count":20,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gyn\u00e4kol Geburtshilfliche Rundsch"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>Die ovarielle Stimulation ist integraler Bestandteil der In-vitro- Fertilisation (IVF)-Behandlung und tr\u00e4gt wesentlich zur Effizienz des Verfahrens bei. In nicht unerheblichem Ausmass verursacht die ovarielle Stimulation jedoch auch Behandlungsrisiken, Nebenwirkungen sowie finanzielle und psychische Belastungen, sodass eine Weiterentwicklung der g\u00e4ngigen Stimulationsprotokolle notwendig ist. In einer selektiven Literatur\u00fcbersicht werden ausgew\u00e4hlte, neue Entwicklungen bei der ovariellen Stimulation diskutiert. Zur Pr\u00e4vention eines ovariellen \u00dcberstimulationssyndroms im Rahmen der IVF kann humanes Choriongonadotropin durch eine Bolusgabe eines Gonadorelin (GnRH)-Agonisten zur Ausl\u00f6sung der finalen Eizellreifung ersetzt werden. Dieses Vorgehen ist nur im GnRH-Antagonisten-Protokoll m\u00f6glich und zeigt in mehreren Studien ein sehr gutes Potenzial zur Pr\u00e4vention des ovariellen Hyperstimulationssyndroms bei Risikopatientinnen. Zur Verringerung der Injektionsh\u00e4ufigkeit von Follikel stimulierendem Hormon (FSH) wurde ein lang wirksames FSH-Molek\u00fcl (carboxyterminales Peptid, FSH-CTP) entwickelt. Phase-III-Daten zeigen, dass FSH-CTP (150 und 100 \u03bcg) \u00fcber mehrere Tage wirkt und \u00e4hnlich effektiv und sicher wie die t\u00e4gliche FSH-Verabreichung im Rahmen der ovariellen Stimulation zur IVF ist. Oral verf\u00fcgbare Luteinisierungshormon- und FSH-Mimetika werden seit geraumer Zeit entwickelt. Eine Anwendung beim Menschen ist bisher nicht publiziert, und die verf\u00fcgbaren Erkenntnisse entstammen In-vitro-Versuchen und Tierexperimenten.<\/jats:p>","DOI":"10.1159\/000197903","type":"journal-article","created":{"date-parts":[[2009,3,25]],"date-time":"2009-03-25T14:41:06Z","timestamp":1237992066000},"page":"55-61","source":"Crossref","is-referenced-by-count":1,"title":["Neue Entwicklungen bei der hormonellen Stimulation"],"prefix":"10.1159","volume":"49","author":[{"given":"G.","family":"Griesinger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Diedrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,3,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2878%2992957-4"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.7221557"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumupd%2Fdml038"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS1472-6483%2810%2961059-0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumrep%2Fdel278"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.fertnstert.2005.07.1292"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2F0301-2115%2895%2902138-W"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.87.2.709"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.fertnstert.2003.05.032"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.fertnstert.2006.05.049"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.fertnstert.2007.02.002"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumupd%2Fdmi045"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumrep%2Fdem006"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.89.10.4304"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumrep%2F16.8.1592"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumrep%2F17.8.1987"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0015-0282%2800%2900542-2"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2003-031766"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2004-0668"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1124%2Fmol.107.039875"}],"container-title":["Gyn\u00e4kologisch-geburtshilfliche Rundschau"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/197903","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/197903","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T23:44:49Z","timestamp":1745451889000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000197903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2009,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000197903","archive":["Portico"],"relation":{},"ISSN":["1018-8843","1423-0011"],"issn-type":[{"type":"print","value":"1018-8843"},{"type":"electronic","value":"1423-0011"}],"subject":[],"published":{"date-parts":[[2009]]}}}