{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:49:49Z","timestamp":1745470189130,"version":"3.40.4"},"reference-count":32,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gyn\u00e4kol Geburtshilfliche Rundsch"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>Die Erfolge bei der Therapie b\u00f6sartiger Erkrankungen haben eine Zunahme des Interesses an der Sicherstellung der Lebensqualit\u00e4t der behandelten Patientinnen und Patienten hervorgerufen. Zum erf\u00fcllten Lebensinhalt und zur Selbstverwirklichung geh\u00f6rt auch die M\u00f6glichkeit zur Fortpflanzung. Sehr oft jedoch vernichten die modernen Behandlungsmethoden eines b\u00f6sartigen Tumorleidens die Bildung von Samenzellen und die Reifung der Eizellen. Wie ansonsten keine andere medizinische Disziplin verf\u00fcgt die Reproduktionsmedizin durch ihre Erfahrung mit der Kryokonservierung von Samenzellen, Eizellen und Embryonen \u00fcber die technische Voraussetzung f\u00fcr die Erhaltung der Fertilit\u00e4t. W\u00e4hrend die Anlage einer Zeugungsreserve bei M\u00e4nnern mit einem b\u00f6sartigen Tumorleiden heute zu einem Standardverfahren geworden ist, sind die M\u00f6glichkeiten bei der Frau noch begrenzt. Die Kryokonservierung von unbefruchteten Eizellen oder von Eizellen im Vorkernstadium ist zwar etabliert, jedoch sind die Erfolgschancen pro Eizelle sehr gering, und die Zeit zwischen der Diagnose des Tumorleidens und dem Beginn der Chemotherapie ist oft zu kurz, um sie f\u00fcr diese Indikation sinnvoll einzusetzen. Die Kryokonservierung von Ovarialgewebe und dessen sp\u00e4tere Retransplantation nach erfolgter Heilung vom Tumorleiden haben mittlerweile zu ersten Erfolgen gef\u00fchrt, sodass jetzt der Beweis der Machbarkeit dieses Vorgehens vorliegt. Ihre weitere Verbreitung h\u00e4ngt nun von der Bildung von Netzwerken ab, in denen Reproduktionsmediziner, Spezialisten der Kryokonservierung von Ovarialgewebe und Onkologen eingebunden sein m\u00fcssen.<\/jats:p>","DOI":"10.1159\/000197906","type":"journal-article","created":{"date-parts":[[2009,3,25]],"date-time":"2009-03-25T14:41:06Z","timestamp":1237992066000},"page":"80-86","source":"Crossref","is-referenced-by-count":0,"title":["Erhaltung der Fertilit\u00e4t bei Tumorerkrankungen"],"prefix":"10.1159","volume":"49","author":[{"given":"C.","family":"De Geyter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"De Geyter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Wight","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,3,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2002-01-0011"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0015-0282%2801%2902987-9"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.bmt.1703677"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.bmt.1705893"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0142%2819991001%2986%3A7%3C1231%3A%3AAID-CNCR18%3E3.0.CO%3B2-Y"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2006-01-0176"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2006.06.5888"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumrep%2F13.11.3256"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumrep%2F16.12.2632"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.11229"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2007-10-115964"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2004.01.159"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.amjsurg.2007.08.031"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2006.08.8344"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2F0029-7844%2895%2900001-8"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ygyno.2006.05.044"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ygyno.2008.04.040"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.fertnstert.2007.02.010"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038%2Fncpendmet0892"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2006.07.7081"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumrep%2F14.10.2665"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2007-0247"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097%2F01.gco.0000193015.96275.2d"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2FS1472-6483%2810%2960765-1"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.fertnstert.2006.03.017"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2F0011-2240%2884%2990079-8"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumrep%2Fden032"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.286.12.1490"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumrep%2Fden244"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2804%2917222-X"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMc055237"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1634%2Ftheoncologist.12-12-1437"}],"container-title":["Gyn\u00e4kologisch-geburtshilfliche Rundschau"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/197906","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/197906","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T23:44:50Z","timestamp":1745451890000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000197906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":32,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2009,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000197906","archive":["Portico"],"relation":{},"ISSN":["1018-8843","1423-0011"],"issn-type":[{"type":"print","value":"1018-8843"},{"type":"electronic","value":"1423-0011"}],"subject":[],"published":{"date-parts":[[2009]]}}}