{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:40:25Z","timestamp":1777866025121,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,1,27]],"date-time":"2009-01-27T00:00:00Z","timestamp":1233014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,1,27]],"date-time":"2009-01-27T00:00:00Z","timestamp":1233014400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"abstract":"<jats:p>This study describes an in vitro experimental model of the sphincter at the lower end of the main pancreatic duct in the dog. This model, employing a drop counter to measure the drop rate, monitors the perfusion rate of Tyrode through the sphincter. Acetylcholine (ACh), employed to establish the sensitivity and viability of the isolated sphincter, produced a contraction of the sphincter which was concentration-response related. Saline, as a control, atropine and hexamethonium did not affect the drop rate. Atropine (20 \u03bcg) partially abolished the contraction produced by 50 \u03bcg of ACh; hexamethonium (50 \u03bcg) did not have an effect. Caerulein 50 \u03bcg produced a relaxation of the sphincter; adrenaline 50 \u03bcg a contraction. Both sympathetic and parasympathetic mechanisms seem to play a role in the regulation of sphincteric activity of the main pancreatic duct in dogs.<\/jats:p>","DOI":"10.1159\/000198113","type":"journal-article","created":{"date-parts":[[2009,1,31]],"date-time":"2009-01-31T10:30:40Z","timestamp":1233397840000},"page":"221-228","source":"Crossref","is-referenced-by-count":2,"title":["Sphincteric Mechanism of the Main Pancreatic Duct in the Dog"],"prefix":"10.1159","author":[{"given":"H.","family":"Sankaran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"FitzGerald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.F.","family":"McGeeney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,1,27]]},"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/198113","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000198113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T07:51:52Z","timestamp":1777535512000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000198113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,27]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000198113","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,27]]}}}