{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:42:15Z","timestamp":1777866135719,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,1,27]],"date-time":"2009-01-27T00:00:00Z","timestamp":1233014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,1,27]],"date-time":"2009-01-27T00:00:00Z","timestamp":1233014400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"abstract":"<jats:p>Determinations of HBeAg, anti-HBe and cell-mediated immune response were carried out in 29 patients with HBsAg-positive chronic active hepatitis. Out of 29 patients with chronic active hepatitis B, 18 were found to be HBeAg positive, 7 anti-HBe positive, and 4 without detectable HBeAg\/anti-HBe by radioimmunoassay. The presence of HBeAg in serum (n = 18) was associated with impaired lymphocyte response in 15 patients (83.3%, p &lt; 0.05). Out of these 15 patients 6 developed cirrhosis within a period of 6 months to 2 years. By contrast, this occurred in only 1 out of 8 HBeAg-negative patients (6 were anti-HBe positive) with normal lymphocyte function. Although HBeAg and depressed cellular immune response in chronic active hepatitis is not necessarily associated with a bad clinical and histological outcome of the disease, these data suggest that, in a number of cases, host cell-mediated immune response seems to be correlated with the presence of HBeAg and the outcome of chronic active hepatitis and, in this respect, HBeAg could assume the significance of a prognostic marker in hepatitis B virus infection.<\/jats:p>","DOI":"10.1159\/000198442","type":"journal-article","created":{"date-parts":[[2009,1,31]],"date-time":"2009-01-31T10:42:55Z","timestamp":1233398575000},"page":"214-220","source":"Crossref","is-referenced-by-count":5,"title":["HBeAg\/Anti-HBe System and Cell-Mediated Immunity in Patients with HBsAg-Positive Chronic Active Hepatitis"],"prefix":"10.1159","author":[{"given":"G.","family":"Pastore","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Tursi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.P.","family":"Loria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Dentico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Fera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Schiraldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,1,27]]},"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/198442","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000198442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T08:05:36Z","timestamp":1777536336000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000198442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,27]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000198442","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,27]]}}}