{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:45:30Z","timestamp":1777866330913,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,1,30]],"date-time":"2009-01-30T00:00:00Z","timestamp":1233273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,1,30]],"date-time":"2009-01-30T00:00:00Z","timestamp":1233273600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"abstract":"<jats:p>Patients with Crohn\u2019s colitis were investigated regarding the relationship between intestinal inflammation, mucosal activity of phospholipase A&lt;sub&gt;2&lt;\/sub&gt; and intestinal permeability to different-sized polyethylene glycols (PEG). Mucosal specimens for phospholipase A&lt;sub&gt;2&lt;\/sub&gt; were obtained at colonoscopy and PEG (590\u2013942 daltons) were deposited in the descending colon. Colonic absorption was measured as urinary output of deposited PEG. Colonic absorption of PEG was higher in these patients, even when the colitis was in remission at colonoscopy, than in ileal Crohn\u2019s disease or control patients. Mucosal phospholipase A&lt;sub&gt;2&lt;\/sub&gt; activity was increased in active colitis, but in the patients with endoscopic remission it was at the same level as in the controls or in the patients with ileal Crohn\u2019s disease. The observations suggest that increased intestinal permeability may be a primary factor in activation of mucosal phospholipase A&lt;sub&gt;2&lt;\/sub&gt; activity and in intestinal inflammation.<\/jats:p>","DOI":"10.1159\/000199881","type":"journal-article","created":{"date-parts":[[2009,1,31]],"date-time":"2009-01-31T12:11:36Z","timestamp":1233403896000},"page":"228-233","source":"Crossref","is-referenced-by-count":21,"title":["Increase in Permeability and Phospholipase A\n                    <sub>2<\/sub>\n                    Activity of Colonic Mucosa in Crohn\u2019s Colitis"],"prefix":"10.1159","author":[{"given":"G.","family":"Olaison","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Leandersson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Sj\u00f6dahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Tagesson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,1,30]]},"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/199881","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000199881","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T08:27:47Z","timestamp":1777537667000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000199881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,30]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000199881","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,30]]}}}