{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:49:58Z","timestamp":1745470198815,"version":"3.40.4"},"reference-count":24,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; The aim of the study was to evaluate the efficacy and safety of lanreotide prolonged release (PR) 30 mg (long-acting lanreotide) in girls with constitutional tall stature (CTS). &lt;i&gt;Methods:&lt;\/i&gt; This open label prospective study included 35 girls (mean age 12.6 years) with CTS and a predicted adult height of &gt;180 cm. Intramuscular injections of lanreotide PR 30 mg were given every 14 days, for a minimum of 12 months and up to 36 months. Adult height was compared with pretreatment predicted height. &lt;i&gt;Results:&lt;\/i&gt; The mean predicted adult height was reduced by 3.8 cm (95% CI 3.7\u20134.9 cm) in the restricted intent-to-treat population. Mean growth velocity decreased from 7.9 \u00b1 1.5 cm\/year at preinclusion to 1.7 \u00b1 2.3 cm\/year at the last visit on treatment (n = 35). Gastrointestinal adverse events and cholelithiasis were reported in 35\/37 patients and 5\/37 patients, respectively. There was 1 withdrawal due to gastrointestinal disorders. &lt;i&gt;Conclusions:&lt;\/i&gt; Biweekly intramuscular lanreotide PR 30 mg given to girls with CTS after the onset of pubertal development reduced adult height as compared with predicted height. Treatment-associated adverse events were consistent with the overall safety profile of lanreotide 30 mg PR and did not deter most patients from long-term treatment.<\/jats:p>","DOI":"10.1159\/000201112","type":"journal-article","created":{"date-parts":[[2009,3,4]],"date-time":"2009-03-04T11:05:48Z","timestamp":1236164748000},"page":"228-236","source":"Crossref","is-referenced-by-count":5,"title":["Long-Acting Lanreotide in Adolescent Girls with Constitutional Tall Stature"],"prefix":"10.1159","volume":"71","author":[{"given":"Jean-Claude","family":"Carel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00eblle","family":"Blumberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muriel","family":"Bougeard-Julien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Rochiccioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Louis","family":"Chaussain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u00efth\u00e9","family":"Tauber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,3,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210%2Fer.19.5.540"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093%2Fije%2F23.6.1242"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.84.12.4379"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-67-3-493"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000181099"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01956408"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1651-2227.1991.tb11933.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2888%2980279-8"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02009654"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2804%2917274-7"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-65-2-355"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1651-2227.1990.tb11435.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2265.1990.tb03753.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1530%2Feje.1.02087"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-68-2-239"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.76.3.721"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.325.7355.70"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004310050740"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199810000-00016"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2878%2981071-3"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.67.11.1357"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.81.3.1206"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2005-837520"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2003-1169-L"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/201112","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/201112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T23:48:17Z","timestamp":1745452097000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000201112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2009,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000201112","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[2009]]}}}