{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:47:13Z","timestamp":1777866433357,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,2,5]],"date-time":"2009-02-05T00:00:00Z","timestamp":1233792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,2,5]],"date-time":"2009-02-05T00:00:00Z","timestamp":1233792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"abstract":"<jats:p>The capacity of the small intestinal mucosa to generate leukotriene B&lt;sub&gt;4&lt;\/sub&gt; (LTB&lt;sub&gt;4&lt;\/sub&gt;) and C&lt;sub&gt;4&lt;\/sub&gt; (LTC&lt;sub&gt;4&lt;\/sub&gt;) in children with coeliac disease (CD) was investigated by measuring the production of LTB&lt;sub&gt;4&lt;\/sub&gt; and LTC&lt;sub&gt;4&lt;\/sub&gt; in intestinal biopsy specimens after stimulation with 10 \u03bcM calcium ionophore A23187. In addition, we examined the relationship between the production of LTB&lt;sub&gt;4&lt;\/sub&gt; and LTC&lt;sub&gt;4&lt;\/sub&gt; in the small intestinal mucosa and symptoms of diarrhoea. LTB&lt;sub&gt;4&lt;\/sub&gt; and LTC&lt;sub&gt;4&lt;\/sub&gt; production was significantly higher in biopsies from patients with active CD than from controls (p &lt; 0.05 and p &lt; 0.01, respectively). There was no significant difference in LTB&lt;sub&gt;4&lt;\/sub&gt; and LTC&lt;sub&gt;4&lt;\/sub&gt; production between patients with inactive CD and controls. In both patients with active CD and controls, no difference in LTB&lt;sub&gt;4&lt;\/sub&gt; and LTC&lt;sub&gt;4&lt;\/sub&gt; production was observed between the patients with and without diarrhoea. These findings suggest that enhanced generation of LTB&lt;sub&gt;4&lt;\/sub&gt; and LTC&lt;sub&gt;4&lt;\/sub&gt; in the small intestinal mucosa may contribute to the pathophysiology of CD but would not be related to the development of diarrhoea.<\/jats:p>","DOI":"10.1159\/000201154","type":"journal-article","created":{"date-parts":[[2009,2,7]],"date-time":"2009-02-07T01:50:30Z","timestamp":1233971430000},"page":"239-242","source":"Crossref","is-referenced-by-count":15,"title":["Leukotriene B\n                    <sub>4<\/sub>\n                    and C\n                    <sub>4<\/sub>\n                    Generation by Small Intestinal Mucosa in Children with Coeliac Disease"],"prefix":"10.1159","author":[{"given":"T.","family":"Shimizu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Beijer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Ryd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Strandvik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,2,5]]},"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/201154","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000201154","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T08:41:00Z","timestamp":1777538460000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000201154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,5]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000201154","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,5]]}}}