{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:11:57Z","timestamp":1759482717218,"version":"3.40.4"},"reference-count":24,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2009,2,19]],"date-time":"2009-02-19T00:00:00Z","timestamp":1235001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,2,19]],"date-time":"2009-02-19T00:00:00Z","timestamp":1235001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; We examined whether nicorandil, which is a hybrid of an adenosine triphosphate-sensitive potassium channel opener and a nitrate, could inhibit major adverse cardiac events (MACE) in maintenance hemodialysis patients with suspected myocardial ischemia. &lt;i&gt;Methods:&lt;\/i&gt; We enrolled 148 asymptomatic patients on maintenance hemodialysis, who had exhibited potential myocardial ischemia as assessed by myocardial fatty acid imaging. The end-point was MACE including cardiac death and non-fatal acute myocardial infarction. A propensity-matched analysis was performed. &lt;i&gt;Results: &lt;\/i&gt;Over a mean duration of follow-up of 2.8 \u00b1 1.6 years in the 82 propensity-matched patients (41 in the nicorandil group and 41 in the non-nicorandil group), we observed 17 cardiac deaths and 12 cases of nonfatal myocardial infarction. The incidence of MACE was lower (p = 0.0365) in the nicorandil group (10\/41, 24.4%) than in the non-nicorandil group (19\/41, 46.3%). On stepwise Cox hazard analysis, MACE was significantly inhibited by administration of nicorandil (hazard risk, 0.387; 95% CI 0.178\u20130.842; p = 0.0168). Kaplan-Meier survival estimates revealed that MACE-free survival rates at 3 years were 80.5 and 58.5% in patients with and without nicorandil, respectively. &lt;i&gt;Conclusions:&lt;\/i&gt; Oral administration of nicorandil may offer new potential for the inhibition of MACE in hemodialysis patients.<\/jats:p>","DOI":"10.1159\/000203074","type":"journal-article","created":{"date-parts":[[2009,2,20]],"date-time":"2009-02-20T19:45:47Z","timestamp":1235159147000},"page":"c212-c221","source":"Crossref","is-referenced-by-count":8,"title":["Clinical Potential of Nicorandil to Inhibit Major Cardiac Events in Hemodialysis Patients with Suspected Myocardial Ischemia"],"prefix":"10.1159","volume":"111","author":[{"given":"Masato","family":"Nishimura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiko","family":"Tokoro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaya","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Imai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Okino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"Iwamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakuo","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiko","family":"Ono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,2,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1440-1681.1979.tb01252.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2F00005344-199104000-00016"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9149%2889%2990200-2"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1161%2Fhc0302.102572"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2802%2908265-X"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clinthera.2007.12.020"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2801%2901634-5"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007%2FBF03164778"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2004.00808.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ajkd.2005.01.019"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1161%2Fhc0402.102975"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2307%2F2335942"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0258%2819981015%2917%3A19%3C2265%3A%3AAID-SIM918%3E3.0.CO%3B2-B"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.74.5.1124"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2897%2900238-6"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2899%2900539-2"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000130154.42061.C6"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159%2F000087579"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097%2F00005344-199510000-00006"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ahj.2005.06.030"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000046047.66958.C3"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000109668.05157.05"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000143629.55725.D9"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2005.00462.x"}],"container-title":["Nephron Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/203074","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/203074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:52:22Z","timestamp":1745448742000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000203074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,19]]},"references-count":24,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2009,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000203074","archive":["Portico"],"relation":{},"ISSN":["1660-2110"],"issn-type":[{"type":"electronic","value":"1660-2110"}],"subject":[],"published":{"date-parts":[[2009,2,19]]}}}