{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T22:20:37Z","timestamp":1778019637889,"version":"3.51.4"},"reference-count":6,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Purpose:&lt;\/i&gt; The vitamin E compound \u03b1-tocopherol inhibits fibroblast growth in vitro. To evaluate its potential benefit in preventing failure of glaucoma filtration surgery, we prospectively investigated the outcome of filtering surgery with postoperative dietary \u03b1-tocopherol supplementation. &lt;i&gt;Patients and Methods:&lt;\/i&gt; Thirty-nine patients (39 eyes) with primary open-angle glaucoma or pseudoexfoliative glaucoma were randomly assigned to two post-(phaco)-trabeculectomy treatment groups. Daily oral intake of 300 mg \u03b1-tocopheryl-acetate (absorbed as \u03b1-tocopherol in the intestine) for 2 months was compared to a placebo preparation in a double-blind trial. The follow-up time was 1 year. Success was defined as intraocular pressure (IOP) \u226418 mm Hg with no medication, no needling revision, and no subconjunctival injection. &lt;i&gt;Results:&lt;\/i&gt; In the tocopherol group, the relative risk for trabeculectomy failure decreased from 1.58 at 2 weeks (p = 0.95) to 1.0 at 1 year. Success rates (67\u201390%) and IOP reduction (mean 39 to 53%) were statistically comparable in the two groups. Considering postoperative complications, no relevant differences were found. &lt;i&gt;Discussion:&lt;\/i&gt; Trabeculectomy and phacotrabeculectomy outcome did not show any differences between \u03b1-tocopherol-supplemented patients and the placebo group.<\/jats:p>","DOI":"10.1159\/000203367","type":"journal-article","created":{"date-parts":[[2009,2,20]],"date-time":"2009-02-20T19:45:47Z","timestamp":1235159147000},"page":"228-232","source":"Crossref","is-referenced-by-count":10,"title":["Dietary Tocopherol Supplementation after Trabeculectomy and Phacotrabeculectomy: Double-Blind Randomized Placebo-Controlled Trial"],"prefix":"10.1159","volume":"223","author":[{"given":"David","family":"Goldblum","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Meyenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Mojon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Tappeiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrice E.","family":"Frueh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,2,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000055569"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159%2F000267899"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00417-005-1165-2"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1089%2Fjop.1998.14.75"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.86.12.1352"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00054753"}],"container-title":["Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/203367","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/203367","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:55:50Z","timestamp":1745448950000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000203367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":6,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2009,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000203367","archive":["Portico"],"relation":{},"ISSN":["0030-3755","1423-0267"],"issn-type":[{"value":"0030-3755","type":"print"},{"value":"1423-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}