{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:07:08Z","timestamp":1791079628320,"version":"4.1.0"},"reference-count":29,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Eosinophilic lung diseases comprise a group of heterogeneous pulmonary disorders linked by increased eosinophils in bronchoalveolar lavage fluid (BALF). There is supporting evidence that natural killer (NK) cells participate in the regulation of eosinophilic inflammation. &lt;i&gt;Objective:&lt;\/i&gt; Our aim was to investigate the relationship between eosinophils and NK cells in BALF in patients with different interstitial lung diseases (ILDs) focusing on eosinophilic pneumonias. &lt;i&gt;Methods:&lt;\/i&gt; Of 114 patients who presented with increased BALF eosinophils (&gt;5%), 74 patients were classified into the following groups: 27 had eosinophilic pneumonia (EP), 17 had idiopathic pulmonary fibrosis (IPF), 16 had hypersensitivity pneumonitis (HSP) and 14 had cryptogenic organizing pneumonia (COP\/BOOP). Total BALF cells, cell density and cell differential counts were assessed and lymphocyte subsets CD3+, CD4+, CD8+, CD19+, CD3\u2013CD16\/56+ (NK) and CD3+CD16\/56+ (NKT) were determined by flow cytometry. &lt;i&gt;Results:&lt;\/i&gt; Significant differences were observed in the percentages of lymphocytes (p &lt; 0.001) and CD3+CD16\/56+ cells (p = 0.023) among patient groups. In patients with EP, the percentage of eosinophils correlated positively with the number of CD3\u2013CD16\/56+ cells (r = 0.522, p = 0.005), the percentage of CD3\u2013CD16\/56+ cells (r = 0.690, p &lt; 0.001), and the absolute count of CD3+CD16\/56+ absolute cells (r = 0.609, p = 0.001). However, in patients with IPF, HSP or COP\/BOOP, no correlation between the percentage of eosinophils and CD3\u2013CD16\/56+ or CD3+CD16\/56+ cells was observed. &lt;i&gt;Conclusions:&lt;\/i&gt; Eosinophil inflammation seems to develop through a different pathway in EP compared to other ILDs.<\/jats:p>","DOI":"10.1159\/000203989","type":"journal-article","created":{"date-parts":[[2009,2,20]],"date-time":"2009-02-20T13:11:19Z","timestamp":1235135479000},"page":"177-184","source":"Crossref","is-referenced-by-count":14,"title":["Bronchoalveolar Lavage Fluid Eosinophils Are Correlated to Natural Killer Cells in Eosinophilic Pneumonias"],"prefix":"10.1159","volume":"78","author":[{"given":"D.","family":"Papakosta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Manika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Kyriazis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Kontakiotis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Gioulekas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Polyzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Bouros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Patakas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,2,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2F00063198-200109000-00002"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1399-3003.1999.13a40.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.96.09122494"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.189.3.553"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2Feji.200324303"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2004.09.004"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.01.00228701"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2Feji.200525994"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1006%2Fcimm.1999.1589"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM196904102801501"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200301-137OC"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.04.00101303"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02718234"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097%2F00005792-199809000-00001"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.03.00105202"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136%2Fthx.48.8.835"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.96.09122437"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.95.08081281"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1398-9995.2003.00149.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.102.3.715"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2FS0954-6111%2898%2990006-3"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.108.1.123"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.07-0128"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1093%2Fintimm%2Fdxh020"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.05.00030805"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1081%2FJAS-200038364"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0510282103"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.188.2.287"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.20011347"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/203989","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/203989","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T23:01:58Z","timestamp":1745449318000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000203989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":29,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2009,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000203989","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}