{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T17:02:45Z","timestamp":1786554165028,"version":"build-2736575974"},"reference-count":27,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aim:&lt;\/i&gt; Interleukin-8 (IL-8), a potent chemoattractant for neutrophils, has been implicated in the pathogenesis of Alzheimer\u2019s disease (AD). The ability of individuals to produce high levels of IL-8 is partially determined by the IL-8 \u2013251 T\/A polymorphism. Therefore, we investigated the association between this polymorphism and AD in a Chinese population. Additionally, in light of the stimulatory effect of homocysteine on the production of IL-8, we also sought to determine whether the methylenetetrahydrofolate reductase (MTHFR) gene 677 C\/T variant, a genetic modifier of the serum homocysteine level, may interact with the IL-8 \u2013251 polymorphism in determining the AD risk. &lt;i&gt;Methods:&lt;\/i&gt; Genotyping of 198 AD patients and 240 matched controls was performed by PCR-RFLP. &lt;i&gt;Results:&lt;\/i&gt; The presence of the MTHFR 677 C\/T and 677 T\/T genotypes conferred a marginally significant increase in the risk for AD (OR = 1.666, 95% CI = 1.022\u20132.715, and OR = 1.892, 95% CI = 1.124\u20133.187) and the presence of the IL-8 \u2013251 polymorphism was not associated with AD. However, the OR for AD associated with joint occurrence of the MTHFR 677 T\/T and the IL-8 \u2013251 A\/A genotypes was 2.512 (95% CI = 1.151\u20135.483). &lt;i&gt;Conclusion:&lt;\/i&gt; Our data suggest a critical role for IL-8\/MTHFR interactions in the development of AD.<\/jats:p>","DOI":"10.1159\/000204766","type":"journal-article","created":{"date-parts":[[2009,2,24]],"date-time":"2009-02-24T18:05:14Z","timestamp":1235498714000},"page":"286-291","source":"Crossref","is-referenced-by-count":31,"title":["Interaction between Interleukin-8 and Methylenetetrahydrofolate Reductase Genes Modulates Alzheimer\u2019s Disease Risk"],"prefix":"10.1159","volume":"27","author":[{"given":"Keshen","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songpo","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binyou","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifen","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,2,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3109%2F13550289909029743"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijdevneu.2005.11.014"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jneuroim.2006.11.017"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.58.11.1790"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.mad.2006.11.013"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI114265"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.63.4.538"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0197-4580%2801%2900306-2"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-4547%2819990101%2955%3A1%3C17%3A%3AAID-JNR3%3E3.0.CO%3B2-J"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jneuroim.2004.10.006"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2004.06.038"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1158%2F1055-9965.EPI-05-0326"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1515%2FCCLM.2003.161"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1161%2F01.RES.0000087642.01082.E4"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038%2Fng0595-111"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.34.7.939"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neurobiolaging.2007.12.010"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1750"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.humimm.2004.01.015"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1136%2Fthorax.55.12.1023"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2006.00482.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cca.2006.08.023"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097%2F00001756-200404090-00025"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002%2Fgps.1903"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1385%2FJMN%3A27%3A1%3A023"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3940%2801%2902316-3"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016%2FS0197-4580%2803%2900040-X"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/204766","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/204766","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T23:09:47Z","timestamp":1745449787000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000204766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":27,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2009,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000204766","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}