{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:18:08Z","timestamp":1773289088868,"version":"3.50.1"},"reference-count":18,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Interleukin-16 (IL-16) is a cytokine that induces selective migration of CD4+ cells and participates in inflammatory diseases including allergic rhinitis. Histamine and prostaglandin D&lt;sub&gt;2&lt;\/sub&gt; are important chemical mediators of allergic inflammation, and antiallergic drugs are commonly used for the treatment of allergic rhinitis. It remains unknown whether treatment with the drugs affects IL-16. &lt;i&gt;Objective:&lt;\/i&gt; We evaluated the variability of IL-16 and the effects of the antiallergic drugs fexofenadine (40 mg\/kg\/day) and ramatroban (30 mg\/kg\/day) on IL-16 in an OVA-sensitized BALB\/c murine experimental allergic rhinitis model. &lt;i&gt;Methods:&lt;\/i&gt; We measured the expression level of IL-16 protein in the mouse nasal septal mucosa by immunohistochemistry, and the serum level of IL-16 by ELISA. Several other parameters associated with allergic rhinitis (nasal symptoms, OVA-specific IgE, eosinophil and T cell infiltration) were also measured. &lt;i&gt;Results:&lt;\/i&gt; Local and systemic expressions of IL-16 were significantly increased in OVA-sensitized mice when compared to the nonsensitized group. Fexofenadine and ramatroban significantly inhibited the following OVA-induced allergic features when compared to the nontreated sensitized group: sneezing, nasal rubbing, eosinophil infiltration, IL-16 expressions in nasal tissue, and serum IL-16 level. Serum OVA-specific IgE and local T cell infiltration were reduced, but they did not reach significant values. &lt;i&gt;Conclusions:&lt;\/i&gt; These results suggest that IL-16 was both systemically and locally upregulated in the murine allergic rhinitis model and that IL-16 changed in parallel to allergic state by treatment with the drugs.<\/jats:p>","DOI":"10.1159\/000205577","type":"journal-article","created":{"date-parts":[[2009,3,18]],"date-time":"2009-03-18T14:14:15Z","timestamp":1237385655000},"page":"315-322","source":"Crossref","is-referenced-by-count":7,"title":["IL-16 Variability and Modulation by Antiallergic Drugs in a Murine Experimental Allergic Rhinitis Model"],"prefix":"10.1159","volume":"149","author":[{"given":"Kosuke","family":"Akiyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Karaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuichi","family":"Kobayshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Dobashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiko","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nozomu","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,3,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F0167-5699%2896%2910052-I"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291521-4141%28199809%2928%3A09%3C2661%3A%3AAID-IMMU2661%3E3.0.CO%3B2-N"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2898%2970282-9"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS1359-6101%2803%2900056-X"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2222.2002.01528.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2567.2005.02269.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2897%2970152-0"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000087359"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1398-9995.2001.00916.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.10.042"},{"key":"ref11"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/506731"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-12-134"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-011-9880-5"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.25.5.1495"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159%2F000024186"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0014-2999%2899%2900547-6"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2002.124770a"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/205577","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/205577","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T23:19:02Z","timestamp":1745450342000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000205577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":18,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2009,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000205577","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}