{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T04:32:29Z","timestamp":1772080349937,"version":"3.50.1"},"reference-count":37,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Flavonoids exert antiallergic and antioxidant effects. We investigated the efficacy of enzymatically modified isoquercitrin (EMIQ), a flavonoid, to relieve symptoms of pollinosis. &lt;i&gt;Methods:&lt;\/i&gt; In a parallel-group, double-blind placebo-controlled study design, 20 subjects with Japanese cedar pollinosis took two capsules daily of 100 mg EMIQ or a placebo for 8 weeks during the pollen season. Subjective symptoms and activities of daily living (ADL) scores were recorded every day, and the quality of life (QOL) score was obtained every 4 weeks. Blood sampling was performed before and after the study to measure serum cytokines, chemokines, IgE, quercetin and oxidized biomarkers. &lt;i&gt;Results:&lt;\/i&gt; During the entire study period, total ocular score and ocular itching score for the EMIQ group were significantly lower (p &lt; 0.05) than for the placebo group. When limited to the individual periods, total symptom score for the EMIQ group was significantly lower (p &lt; 0.05, week 4\u20135) than that for the placebo group while other scores for the EMIQ group, such as total nasal score (p = 0.06, week 4\u20135), nasal obstruction score (p = 0.08, week 4\u20135), lacrimation score (p = 0.06, week 5\u20136), ocular congestion score (p = 0.08, week 4\u20137) and ADL score (p = 0.08, week 4\u20137), all tended to be lower. The levels of serum cytokines such as interleukin (IL)-4, IL-5, IL-12, IL-13, interferon-\u03b3, and eotaxin and IgE were not significantly downregulated by the intake of EMIQ but the serum concentrations of oxidized low-density lipoprotein and thymus and activation-regulated chemokine were reduced. &lt;i&gt;Conclusion:&lt;\/i&gt; Intake of the quercetin glycoside EMIQ was safe and influenced ocular symptoms caused by pollinosis.<\/jats:p>","DOI":"10.1159\/000205582","type":"journal-article","created":{"date-parts":[[2009,3,18]],"date-time":"2009-03-18T14:14:15Z","timestamp":1237385655000},"page":"359-368","source":"Crossref","is-referenced-by-count":38,"title":["Effect of Enzymatically Modified Isoquercitrin, a Flavonoid, on Symptoms of Japanese Cedar Pollinosis: A Randomized Double-Blind Placebo-Controlled 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