{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T21:03:34Z","timestamp":1777755814492,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,2,24]],"date-time":"2009-02-24T00:00:00Z","timestamp":1235433600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,2,24]],"date-time":"2009-02-24T00:00:00Z","timestamp":1235433600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"abstract":"<jats:p>Fetal haemoglobin (Hb F) and its G\u03b3-globin chain contents were examined in 2 juvenile (JCML) and 9 adult chronic myelogenous leukaemia (ACML) patients. One JCML patient\u2019s %Hb F was 28.0% and its %G\u03b3 was 41.8%, while another JCML patient\u2019s %Hb F was 58.0% and its % G\u03b3 was 65.6%. Four ACML patients showed slightly elevated %Hb F (3.4-4.6%). The % G\u03b3 was low in 3 ACML patients analysed (9.9\u201314.1 %). The \u03b3-globin gene arrangements in all cases were normal. The presence of the Xmn I site 5\u2019 to the G\u03b3-globin gene (at -158 base pairs from the G\u03b3-globin gene cap site) was observed only in 1 typical JCML patient with elevated %G\u03b3. The subhaplotype 5\u2019 to the \u03b4-globin gene in 5 ACML patients was [+ \u2013 \u2013 \u2013 -], and the other 4 were suspected to be heterozygotes for [+ \u2013 \u2013 \u2013 -] and [ + + \u2013 +]. The frequency of the A\u03b3\u03a4-globin gene in ACML patients may be higher than in the normal Japanese population.<\/jats:p>","DOI":"10.1159\/000205594","type":"journal-article","created":{"date-parts":[[2009,2,24]],"date-time":"2009-02-24T13:05:14Z","timestamp":1235480714000},"page":"28-33","source":"Crossref","is-referenced-by-count":2,"title":["Elevated Haemoglobin F in Juvenile and Adult Chronic Myelogenous Leukaemia"],"prefix":"10.1159","author":[{"given":"K.","family":"Shimizu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Keino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Terasawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Shichishima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Ikuta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,2,24]]},"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/205594","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000205594","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:15:55Z","timestamp":1777464955000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000205594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,24]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000205594","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,24]]}}}