{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T07:15:50Z","timestamp":1786346150448,"version":"build-2736575974"},"reference-count":22,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2009]]},"abstract":"<i>Background:<\/i> Recent studies suggest that a low antioxidant level in preterm infants may predispose them to increased oxidative stress and results in hyperbilirubinemia, whereas glucose-6-phosphate dehydrogenase (G6PD) activity was found to be higher in preterm infants than in term infants. <i>Objectives:<\/i> To evaluate (1) the oxidative effect of \u03b1-naphthol on preterm and term red blood cells, and (2) the relationship between G6PD activity and the gestational age of these infants. <i>Methods:<\/i> G6PD activities were determined in preterm and term infants by a standard diagnostic method. Whole blood samples were incubated with \u03b1-naphthol for 2 h and their pre- and post-challenged reduced glutathione (GSH) levels were quantified. <i>Results:<\/i> The mean G6PD activity in preterm infants (n = 113; 13.52 \u00b1 0.19 U\/g Hb; gestational age 30.67 \u00b1 0.28 weeks) was significantly higher than that in term infants (n = 100; 12.36 \u00b1 0.16 U\/g Hb; gestational age 39.82 \u00b1 0.14 weeks; p < 0.001). A significantly negative correlation was demonstrated between gestational age and G6PD activity (r = \u20130.34, p < 0.001). GSH levels of preterm and term subjects were similar at baseline, but were significantly decreased upon challenge with \u03b1-naphthol (p < 0.001). The percentage reduction in GSH levels was similar in the various gestational age groups. <i>Conclusions:<\/i> Our data show that G6PD activities had a negative correlation with gestational age of G6PD-normal infants. The similar response of preterm and term erythrocytes to an \u03b1-naphthol challenge indicates the manifestation of an active anti-oxidative pathway mediated by cellular GSH.<\/jats:p>","DOI":"10.1159\/000205720","type":"journal-article","created":{"date-parts":[[2009,3,4]],"date-time":"2009-03-04T11:05:48Z","timestamp":1236164748000},"page":"96-101","source":"Crossref","is-referenced-by-count":12,"title":["Oxidative Challenge and Glucose-6-Phosphate Dehydrogenase Activity of Preterm and Term Neonatal Red Blood Cells"],"prefix":"10.1159","volume":"96","author":[{"given":"Chun Hay","family":"Ko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond Pui-On","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pak Cheung","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kit Man","family":"Chui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick Man-Pan","family":"Yuen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai Fai","family":"Fok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,3,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2F00006205-199904000-00003"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2F0378-3782%2887%2990050-8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.114.1.e130"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2867%2980410-4"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0378-3782%2803%2900009-4"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1157%2F13084171"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-079X.2005.00251.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1440-1754.2004.00489.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093%2Ftropej%2F49.2.74"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0268-960X%2896%2990019-3"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.2004.049148"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.freeradbiomed.2003.08.013"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000075814"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bcmd.2006.04.007"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00439011"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2862%2980370-9"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1553-2712.2000.tb01889.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002%2Fbiof.5520080122"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1515%2FJPM.2002.071"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159%2F000244422"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1203%2F01.PDR.0000016664.46604.01"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1093%2Ftropej%2F42.1.43"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/205720","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/205720","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T23:18:19Z","timestamp":1745450299000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000205720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":22,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2009,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000205720","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}