{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T21:08:30Z","timestamp":1777756110845,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,2,25]],"date-time":"2009-02-25T00:00:00Z","timestamp":1235520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,2,25]],"date-time":"2009-02-25T00:00:00Z","timestamp":1235520000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"abstract":"<jats:p>This study was conducted in the Eastern Province of Saudi Arabia where both thalassaemia and Hb S genes occur at a high frequency. In 171 Saudi Hb S heterozygotes, the range for Hb S was found to be 17\u201345% with a mean of 31.0%. Frequency distribution histograms showed a trimodal distribution. Peak A, B and C had 18\u201328, 28\u201335 and 35\u201345% Hb S values, respectively. Determination of \u03b1\/\u03b2 ratio showed that these findings result from interaction of Hb S with the \u03b1-thalassaemia gene. Peak C with mean for Hb S of 40% consisted of a majority of individuals with no thalassaemia gene, and the \u03b1\/\u03b2 ratio was 0.98% \u00b1 0.06. Peak B individuals were heterozygous for \u03b1-thalassaemia 2 with an \u03b1\/\u03b2 ratio of 0.80%) \u00b1 0.06 and peak A individuals were homozygous to \u03b1-thalassaemia 2 with an \u03b1\/\u03b2 ratio of 0.58 \u00b1 0.08. The presence of \u03b1-thalassaemia 2 in homozygotes results in hypochromia and microcytosis, with little effect on haematological parameters.<\/jats:p>","DOI":"10.1159\/000206095","type":"journal-article","created":{"date-parts":[[2009,2,25]],"date-time":"2009-02-25T09:37:40Z","timestamp":1235554660000},"page":"100-104","source":"Crossref","is-referenced-by-count":2,"title":["Studies on Sickle Cell Heterozygotes in Saudi Arabia \u2013 Interaction with \u03b1-Thalassaemia"],"prefix":"10.1159","author":[{"given":"M.A.F.","family":"El-Hazmi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,2,25]]},"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/206095","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000206095","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:21:31Z","timestamp":1777465291000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000206095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,25]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000206095","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,25]]}}}