{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T15:57:42Z","timestamp":1758124662068,"version":"3.40.4"},"reference-count":10,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background and Aim:&lt;\/i&gt; Although mucoprotective agents are commonly used against gastric and duodenal lesions in Japan, their availability as agents for non-steroidal anti-inflammatory drug (NSAID)-induced gastrointestinal damage has not been clarified. To investigate the effect of irsogladine maleate (IM) on gastric mucosal blood flow (GMBF) reduction induced by diclofenac sodium, a NSAID commonly used in Japan, by laser Doppler flowmetry (LDF) and ultrasonography (US) in canine stomach. &lt;i&gt;Methods:&lt;\/i&gt; GMBF was measured by LDF and contrast-enhanced US in 15 beagles. US was performed employing real-time harmonic imaging under low acoustic power after intravenous contrast injection using Definity\u2122 (60 mg\/kg). 60 min after insertion of a diclofenac sodium suppository (1.0 mg\/kg) into the rectum, LDF and contrast-enhanced US were repeated. The examination was done in a crossover, single-blinded fashion. &lt;i&gt;Results:&lt;\/i&gt; The mean extent of the change in GMBF in the IM group and in the placebo group was +29.3 and \u201338%, respectively. &lt;i&gt;Conclusions:&lt;\/i&gt; IM alleviates the reduction of GMBF induced by diclofenac sodium.<\/jats:p>","DOI":"10.1159\/000206823","type":"journal-article","created":{"date-parts":[[2009,3,6]],"date-time":"2009-03-06T11:52:52Z","timestamp":1236340372000},"page":"73-78","source":"Crossref","is-referenced-by-count":9,"title":["Effect of Irsogladine Maleate on NSAID-Induced Reduction of Gastric Mucosal Blood Flow in Anesthetized Dogs"],"prefix":"10.1159","volume":"79","author":[{"given":"Motonori","family":"Sato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriaki","family":"Manabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiro","family":"Hata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoari","family":"Kamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Kusunoki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Shiotani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Haruma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,3,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093%2Faje%2Fkwh005"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1152%2Fphysrev.00004.2008"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2036.2005.02475.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1254%2Fjjp.77.293"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1254%2Fjphs.93.314"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000200681"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3109%2F00365528809090192"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1080%2F00365520500464975"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1080%2F00365520701216968"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1440-1746.2007.05201.x"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/206823","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/206823","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T23:31:07Z","timestamp":1745451067000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000206823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":10,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2009,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000206823","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"type":"print","value":"0012-2823"},{"type":"electronic","value":"1421-9867"}],"subject":[],"published":{"date-parts":[[2009]]}}}