{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T07:34:33Z","timestamp":1773300873889,"version":"3.50.1"},"reference-count":21,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blood Purif"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Increased plasma total homocysteine (tHcy) is a risk factor for the development of atherosclerosis and thrombosis present in over 90% of patients with end-stage renal disease (ESRD). We hypothesized that 12 mg\/kg intravenous mesna administered predialysis would cause a significant decrease in plasma tHcy compared to placebo. &lt;i&gt;Methods:&lt;\/i&gt; Patients with ESRD were recruited for 1- and 4-week placebo-controlled, cross-over studies. Intravenous 12 mg\/kg mesna or placebo was administered 3 times weekly predialysis. &lt;i&gt;Results:&lt;\/i&gt; One week of 12 mg\/kg intravenous mesna significantly decreased predialysis plasma tHcy by 12.8 \u00b1 7.8% (placebo 23.4 \u00b1 8.0 \u03bcmol\/l vs. mesna 20.5 \u00b1 7.6 \u03bcmol\/l, p = 0.0044). Four weeks of treatment yielded no significant decline in predialysis plasma tHcy (placebo 18.3 \u00b1 8.5 \u03bcmol\/l vs. mesna 18.7 \u00b1 6.3 \u03bcmol\/l, p = 0.41). &lt;i&gt;Conclusions:&lt;\/i&gt; Although 12 mg\/kg mesna significantly enhances tHcy excretion, prolonged treatment causes no change in plasma tHcy.<\/jats:p>","DOI":"10.1159\/000207197","type":"journal-article","created":{"date-parts":[[2009,3,6]],"date-time":"2009-03-06T11:52:52Z","timestamp":1236340372000},"page":"306-310","source":"Crossref","is-referenced-by-count":5,"title":["Mesna for the Treatment of Hyperhomocysteinemia in Hemodialysis Patients"],"prefix":"10.1159","volume":"27","author":[{"given":"Murray J.","family":"Cutler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley L.","family":"Urquhart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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