{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T21:20:31Z","timestamp":1777756831305,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,2,27]],"date-time":"2009-02-27T00:00:00Z","timestamp":1235692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,2,27]],"date-time":"2009-02-27T00:00:00Z","timestamp":1235692800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"abstract":"<jats:p>We examined the relationship between blood volume, mean haemoglobin maintained and transfusion requirement in an extensive series (166 cases) of uniformly treated patients with homozygous \u03b2-thalassaemia. The blood volume is increased in all the subjects and this increase appears inversely proportional to the mean haemoglobin level maintained. When this is above 12g\/dl, the blood volume is nearly normal. The transfusion requirement of patients kept between 10 and 14 g\/dl is constant. Maintenance of a high haemoglobin level in thalassaemic patients inhibits erythropoiesis to a considerable degree with a reduction of the haemopoietic tissue and hence of the total blood volume.<\/jats:p>","DOI":"10.1159\/000207218","type":"journal-article","created":{"date-parts":[[2009,2,27]],"date-time":"2009-02-27T04:37:06Z","timestamp":1235709426000},"page":"103-108","source":"Crossref","is-referenced-by-count":14,"title":["Correlation between Transfusion Requirement, Blood Volume and Haemoglobin Level in Homozygous \u03b2-Thalassaemia"],"prefix":"10.1159","author":[{"given":"Vilma","family":"Gabutti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Piga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Fortina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Miniero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Nicola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,2,27]]},"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/207218","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000207218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:35:42Z","timestamp":1777466142000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000207218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,27]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000207218","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,27]]}}}