{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T07:49:43Z","timestamp":1791013783681,"version":"4.1.0"},"reference-count":16,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; Post-operative nausea and vomiting are common adverse events that require administration of anti-emetic compounds, such as the serotonin 5-HT&lt;sub&gt;3&lt;\/sub&gt; receptor antagonists, but these drugs can also reduce the analgesic efficacy of some analgesics (paracetamol, tramadol). &lt;i&gt;Methods:&lt;\/i&gt; The present study was designed to explore the effect of 3 serotonin 5-HT&lt;sub&gt;3&lt;\/sub&gt; receptor antagonists on the antinociceptive efficacy of another frequently used post-operative analgesic, nefopam, in the mouse writhing and formalin tests. &lt;i&gt;Results:&lt;\/i&gt; Pre-treatment with tropisetron, ondansetron or MDL72222 did not significantly modify nefopam antinociception in both tests. However, paracetamol antinociception was blocked by ondansetron in the formalin test. &lt;i&gt;Conclusion:&lt;\/i&gt; These results provide a rationale for the clinical use of nefopam with anti-emetics during surgery.<\/jats:p>","DOI":"10.1159\/000207448","type":"journal-article","created":{"date-parts":[[2009,3,6]],"date-time":"2009-03-06T11:52:52Z","timestamp":1236340372000},"page":"243-246","source":"Crossref","is-referenced-by-count":16,"title":["Modulation of Paracetamol and Nefopam Antinociception by Serotonin 5-HT&lt;sub&gt;3&lt;\/sub&gt; Receptor Antagonists in Mice"],"prefix":"10.1159","volume":"83","author":[{"given":"Philippe","family":"Girard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick","family":"Pansart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Claude","family":"Copp\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty","family":"Niedergang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marie","family":"Gillardin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,3,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clpt.2005.12.307"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ejpain.2005.10.002"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F00000539-200206000-00033"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1006%2Fphrs.2001.0886"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1089%2F089771503767168519"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1213%2F01.ANE.0000093780.67532.95"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093%2Fbja%2Faeg264"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1213%2F01.ANE.0000138037.19757.ED"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2F0028-3908%2893%2990064-A"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00726-005-0166-0"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.brainres.2004.04.035"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.clpt.6100403"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0014-2999%2802%2901578-9"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00011-003-1185-5"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.phrs.2006.04.008"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-8993%2899%2901839-9"}],"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/207448","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/207448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T23:38:03Z","timestamp":1745451483000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000207448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":16,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2009,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000207448","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}