{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T21:23:24Z","timestamp":1777757004655,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,3,3]],"date-time":"2009-03-03T00:00:00Z","timestamp":1236038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,3,3]],"date-time":"2009-03-03T00:00:00Z","timestamp":1236038400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"abstract":"<jats:p>Two conditions are liable to lower the \u03b1:\u03b2 globin biosynthesis ratio in reticulocytes: iron deficiency and \u03b1-thalassaemia. The present paper studies the effect of haemin on reticulocytes from 12 patients who have \u03b1-thalassaemia and\/or are iron deficient. The \u03b1:\u03b2 globin biosynthesis ratio was improved in all these cases. 4 showed initially an \u03b1:\u03b2 synthesis ratio usually associated with \u03b1-thalassaemia type-1; on the addition of haemin the ratio rose to that associated with \u03b1-thalassaemia type-2. In the other 8 patients the ratio was initially typical for \u03b1-thalassaemia type-2, and on addition of haemin the ratio became normal. It is suggested that in iron deficient patients a diagnosis of \u03b1-thalassaemia type-1 or type-2 cannot be made unless haemin has been added to the test system. If this is not done iron deficiency alone can cause the \u03b1:\u03b2 globin synthesis ratio to resemble that associated with \u03b1-thalassaemia ty\u03c1e-2, and iron deficiency in combination with \u03b1-thalassaemia type-2 can cause the ratio to resemble that typical for \u03b1-thalassaemia type-1. Reticulocytes from 8 \u03b1-thalassaemic patients without iron deficiency did not show a marked haemin effect \u00ab5%), and in 1 patient with iron overload, the ratio actually fell by about 10%.<\/jats:p>","DOI":"10.1159\/000207689","type":"journal-article","created":{"date-parts":[[2009,3,4]],"date-time":"2009-03-04T06:05:48Z","timestamp":1236146748000},"page":"1-9","source":"Crossref","is-referenced-by-count":11,"title":["Interaction between Iron Deficiency and \u03b1-Thalassaemia: the in vitro Effect of Haemin on \u03b1-Chain Synthesis"],"prefix":"10.1159","author":[{"given":"M.A.F.","family":"El-Hazmi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Lehmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,3,3]]},"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/207689","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000207689","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:38:40Z","timestamp":1777466320000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000207689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,3]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000207689","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,3]]}}}