{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T21:28:02Z","timestamp":1777757282094,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,3,4]],"date-time":"2009-03-04T00:00:00Z","timestamp":1236124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,3,4]],"date-time":"2009-03-04T00:00:00Z","timestamp":1236124800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"abstract":"<jats:p>A 59-year-old man with \u03b2 -thalassaemia major is unusually well. He has no \u03b3 -chains in his haemoglobin but is heterozygous for the genes responsible for \u03b1A and for \u03b1G Philadelphia. In addition he is also heterozygous for the genes responsible for \u03b3F and a new \u03b3-chain, \u03b375 (E19) Ile \u2013 Thr, named \u03b3F.Sardinia. It was not possible to isolate the mutant \u03b3-chain, but from the overall ratios of G\u03b3-:A\u03b3-Chain and \u03b375Ile : \u03b375 Thr&lt;sub&gt;;&lt;\/sub&gt; it could be inferred that the mutation had presumably occured in the G\u03b3-chain. Some of the propositus\u2019 siblings have high levels of Hb A&lt;sub&gt;2&lt;\/sub&gt;, and it is suggested that they possibly carry a gene for a Lepore chain with the \u03b4\u03b2 -crossover after residue \u03b4126.<\/jats:p>","DOI":"10.1159\/000208204","type":"journal-article","created":{"date-parts":[[2009,3,4]],"date-time":"2009-03-04T06:05:48Z","timestamp":1236146748000},"page":"347-355","source":"Crossref","is-referenced-by-count":56,"title":["A New Hb Variant: Hb F Sardinia \u03b375 (e 19) Isoieucine\u2192Threonine Found in a Family with Hb G Philadelphia, \u03b2-Chain Deficiency and a Lepore-Like Haemoglobin Indistinguishable from Hb A\n                    <sub>2<\/sub>"],"prefix":"10.1159","author":[{"given":"V.","family":"Grifoni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Kamuzora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Lehmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Charlesworth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,3,4]]},"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/208204","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000208204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:44:19Z","timestamp":1777466659000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000208204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,4]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000208204","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,4]]}}}