{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T21:30:53Z","timestamp":1777757453989,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,3,5]],"date-time":"2009-03-05T00:00:00Z","timestamp":1236211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,3,5]],"date-time":"2009-03-05T00:00:00Z","timestamp":1236211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"abstract":"<jats:p>After a review of the literature, a series of 21 patients with ITP treated with non-steroidal immunodepressive agents is presented. The agents were azathioprine (AZP), methotrexate (MTX), cyclophosphamide (CPH), vinblastine (VLB) and L-asparaginase (L-ase). No permanent, unmaintained remission in chronic, self-perpetuating cases of ITP could be obtained, even after splenectomy. However, AZP was useful in the treatment of chronic cases, either alone or in combination with steroids, where it displayed a useful steroid sparing effect. CPH and MTX were generally ineffective. VLB induced striking temporary thrombocytoses, and L-ase was followed by an early thrombocytosis, but proved too toxic to be employed consistently. Single case reports and remission percentages are reported.<\/jats:p>","DOI":"10.1159\/000208563","type":"journal-article","created":{"date-parts":[[2009,3,6]],"date-time":"2009-03-06T06:52:52Z","timestamp":1236322372000},"page":"74-91","source":"Crossref","is-referenced-by-count":24,"title":["Clinical Experiences with Cytotoxic Immunosuppressive Treatment of Idiopathic Thrombocytopenic Purpura"],"prefix":"10.1159","author":[{"given":"A.M.","family":"Marmont","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.E.","family":"Damasio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,3,5]]},"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/208563","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000208563","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:47:31Z","timestamp":1777466851000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000208563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,5]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000208563","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,5]]}}}