{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T19:24:18Z","timestamp":1774639458842,"version":"3.50.1"},"reference-count":18,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2009]]},"abstract":"<i>Background:<\/i> Magnesium sulfate (MgSO<sub>4<\/sub>) is used therapeutically for eclampsia and tocolysis. Some reports have suggested a relationship between therapeutic MgSO<sub>4<\/sub> and patent ductus arteriosus (DA) in preterm infants. <i>Objectives:<\/i> To clarify patent DA induction by MgSO<sub>4<\/sub> in preterm infants, we studied the increase in serum Mg concentrations and fetal dilatation and postnatal delayed closure of the ductus, using transplacental MgSO<sub>4<\/sub> in rats. <i>Methods:<\/i> Fetal and neonatal ductus diameters were measured with a microscope and a micrometer after rapid whole-body freezing. In the postnatal study, 21-day pregnant dams were administered a subcutaneous injection of MgSO<sub>4<\/sub> 1\u20133 h before delivery, and the ductus was studied 0, 15, 30, 60 and 120 min after birth. In the fetal study, MgSO<sub>4<\/sub> (1 g\/kg) and indomethacin (10 mg\/kg) were simultaneously administered to 21-day dams and the fetal ductus was studied 1, 2 and 4 h later. Serum Mg concentration was measured in the dams and newborns. <i>Results:<\/i> Neonatal Mg concentrations increased from 3.8 to 4.7 and 5.8 mg\/dl at 1 and 3 h after maternal administration of MgSO<sub>4<\/sub>. Following MgSO<sub>4<\/sub> administration 3 h before birth, closure of the neonatal DA was delayed. The ductus diameter was 0.88 mm (0.80 mm in control) at 0 min, and 0.26 mm (0.08 mm in the control) at 60 min after birth. In the fetal study, MgSO<sub>4<\/sub> initially reversed and later attenuated the ductus-constricting effect of indomethacin. <i>Conclusions:<\/i> Hypermagnesemia induced by transplacental MgSO<sub>4<\/sub> attenuates the fetal ductus-constricting effects of indomethacin, and delays postnatal ductal closure in rats.<\/jats:p>","DOI":"10.1159\/000208794","type":"journal-article","created":{"date-parts":[[2009,3,11]],"date-time":"2009-03-11T16:12:58Z","timestamp":1236787978000},"page":"125-131","source":"Crossref","is-referenced-by-count":7,"title":["Fetal Reversed Constrictive Effect of Indomethacin and Postnatal Delayed Closure of the Ductus Arteriosus following Administration of Transplacental Magnesium Sulfate in Rats"],"prefix":"10.1159","volume":"96","author":[{"given":"Katsuaki","family":"Toyoshima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Momma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Nakanishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,3,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0277-9536(93)90033-Z"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3109\/14992027.2010.510147"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2165%2F00003088-200038040-00002"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.jp.7211663"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1080%2F08035250121590"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0029-7844%2899%2900329-4"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199909000-00010"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-198101000-00005"},{"key":"ref9"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-304219"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0029-7844%2802%2902212-3"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097%2F00003081-199912000-00008"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1203%2F01.PDR.0000156370.50874.3C"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000089954"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000101526"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-197704000-00276"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2880%2980835-3"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-1002-3"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/208794","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/208794","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T23:52:57Z","timestamp":1745452377000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000208794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":18,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2009,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000208794","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}