{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T03:24:05Z","timestamp":1752981845897,"version":"3.40.4"},"reference-count":18,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2009]]},"abstract":"<i>Objectives:<\/i> The effect of second pregnancy on human papillomavirus (HPV) carriage and outcome is modelled in longitudinal setting covering two subsequent pregnancies. <i>Study Design:<\/i> Among 329 (baseline pregnant) women prospectively followed up inthe Finnish Family HPV Study, two subcohorts were compiled: (i) 78 women (Group B) who became pregnant for the second time during the follow-up, and (ii) 100 women (Group A) who did not develop 2nd pregnancy. The effect of pregnancy on high-risk HPV (HR-HPV) carriage and outcome was analysed using Kaplan-Meier and Cox survival analyses and generalized estimating equation (GEE) modelling of the longitudinal data. <i>Results:<\/i> Women in the two groups were similar in their baseline HR-HPV status but significantly different in several known risk factors of HR-HPV infection. Group A women showed higher point prevalence of cervical and oral HR-HPV at the 36-month (p = 0.015) and 6-month (p = 0.024) follow-up visit, respectively. Among Group B women, prevalence of both cervical and oral HR-HPV significantly decreased during 2nd pregnancy (p = 0.005 and p = 0.002) as compared with inter-pregnancy period, but increased again after 2nd pregnancy. There was no difference in acquisition or clearance of cervical or oral HR-HPV between the two groups in univariate (Kaplan-Meier) or multivariate (Cox) survival analysis. In the GEE approach, 2nd pregnancy was not significantly associated with cervical or oral HR-HPV carriage or persistence when adjusted for all other covariates. <i>Conclusions:<\/i> Second pregnancy is of little impact on carriage and persistence of oral and cervical HR-HPV infections in a longitudinal setting over time.<\/jats:p>","DOI":"10.1159\/000209204","type":"journal-article","created":{"date-parts":[[2009,3,13]],"date-time":"2009-03-13T13:16:36Z","timestamp":1236950196000},"page":"208-216","source":"Crossref","is-referenced-by-count":13,"title":["Effect of Second Pregnancy on Maternal Carriage and Outcome of High-Risk Human Papillomavirus (HPV)"],"prefix":"10.1159","volume":"67","author":[{"given":"Marja E.","family":"Sarkola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seija E.","family":"Gr\u00e9nman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjut A.M.","family":"Rintala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari J.","family":"Syrj\u00e4nen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stina M.","family":"Syrj\u00e4nen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,3,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002%2Fijc.2910400212"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2Fjmv.1890280409"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2F0020-7292%2896%2902694-X"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097%2F01.olq.0000179888.47309.db"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2007-999478"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fjmv.1890460203"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1006%2Fgyno.1996.0055"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1086%2F517266"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2Fjmv.10142"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1515%2FJPM.2006.010"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jcv.2005.05.012"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1128%2FJCM.43.1.376-381.2005"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093%2Fnar%2F16.3.1215"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1006%2Fgyno.1998.5264"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1080%2F10647440400009896"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002%2Fsim.1409"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumupd%2Fdmg026"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.bjc.6600367"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/209204","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/209204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T23:57:11Z","timestamp":1745452631000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000209204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":18,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2009,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000209204","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"type":"print","value":"0378-7346"},{"type":"electronic","value":"1423-002X"}],"subject":[],"published":{"date-parts":[[2009]]}}}