{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T07:14:50Z","timestamp":1789629290580,"version":"build-2803163510"},"reference-count":33,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Recognizing heart disease is relevant to pulmonologists because many patients suspected to have dyspnea of pulmonary origin harbor heart disease. &lt;i&gt;Objectives:&lt;\/i&gt; To investigate the role of N-terminal pro-brain natriuretric peptide (NT-proBNP) in identifying heart disease and cardiac causes of dyspnea among patients referred for evaluation by a pulmonologist. &lt;i&gt;Methods:&lt;\/i&gt; 697 consecutive outpatients (aged 57.5 \u00b1 16.4 years) with chronic dyspnea prospectively underwent a diagnostic work-up for heart and lung diseases. &lt;i&gt;Results:&lt;\/i&gt; The prevalence of patients with heart disease was 25.3%. The cardiac findings were placed into 6 groups which were associated with an increase in NT-proBNP in the following order: (1) left ventricular hypertrophy [regression coefficient (\u03b2) = 0.33, p = 0.03]; (2) exercise-induced myocardial ischemia (\u03b2 = 0.73, p = 0.02);(3) valvular or congenital heart disease or pericardial effusion (\u03b2 = 0.93, p &lt; 0.0001); (4) pulmonary hypertension (\u03b2 = 1.14, p &lt; 0.0001); (5) atrial fibrillation or left bundle branch block (\u03b2 = 1.22, p &lt; 0.0001), and (6) left ventricular systolic dysfunction (\u03b2 = 1.94, p &lt; 0.0001). Using predefined cut-off values of 93 pg\/ml (men) and 144 pg\/ml (women), sensitivity was 0.75 and specificity was 0.79 for identifying heart disease. The negative predictive value was 0.90. If heart disease had to be considered as a cause of the dyspnea, sensitivity and the negative predictive value went up to 0.90 and 0.97, respectively. &lt;i&gt;Conclusions:&lt;\/i&gt; NT-proBNP performs well as a test for ruling out cardiac dyspnea. It is also useful as a rule-in test for heart disease, which enables the pulmonologist to appropriately select candidates for in-depth evaluation by cardiology.<\/jats:p>","DOI":"10.1159\/000209339","type":"journal-article","created":{"date-parts":[[2009,3,27]],"date-time":"2009-03-27T09:30:08Z","timestamp":1238146208000},"page":"370-380","source":"Crossref","is-referenced-by-count":8,"title":["NT-proBNP for Pulmonologists: Not Only a Rule-Out Test for Systolic Heart Failure but Also a Global Marker of Heart Disease"],"prefix":"10.1159","volume":"77","author":[{"given":"Siegfried","family":"Wieshammer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Dreyhaupt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"Basler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emil","family":"Marsovszky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,3,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cardfail.2005.04.022"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ejheart.2005.01.022"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jacc.2003.05.011"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS1076-6332%2803%2980087-9"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093%2Feurheartj%2Fehi291"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.annepidem.2005.04.008"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa031994"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2803%2900486-8"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijcard.2007.07.174"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.amjcard.2004.05.055"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097%2F01.hjh.0000125451.28861.2a"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0954-6111%2899%2990094-X"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0009-8981%2800%2900312-0"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9149%2802%2902464-5"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jacc.2003.10.066"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ejheart.2003.10.003"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186%2Fcc3000"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa020233"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093%2Feurheartj%2Fehi631"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa031681"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.106.666255"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jacc.2007.07.073"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1067%2Fmje.2000.104535"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1136%2Fjcp.2005.034702"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijcard.2005.12.014"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ejheart.2007.01.010"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ejheart.2008.07.014"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijcard.2007.10.006"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.125.6.2309"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1136%2Fhrt.2003.026021"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa042741"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jacc.2003.07.037"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1093%2Feurheartj%2Fehm037"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/209339","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/209339","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:40:22Z","timestamp":1745448022000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000209339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":33,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2009,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000209339","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}