{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:46:50Z","timestamp":1745470010506,"version":"3.40.4"},"reference-count":8,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Objectives:&lt;\/i&gt; To evaluate the impact of antibiotic treatment in patients with higher-than-normal prostate-specific antigen (PSA) levels in terms of changes both in total PSA and free\/total (f\/t) PSA ratios. &lt;i&gt;Materials and Methods:&lt;\/i&gt; Serum PSA and f\/t PSA changes after antibiotic treatment in 85 patients with normal digital rectal examination but elevated age-adjusted serum PSA levels were evaluated with relevance to biopsy results. &lt;i&gt;Results:&lt;\/i&gt; Serum PSA levels decreased after antibiotic treatment in 47 of 85 patients. The f\/t PSA ratio decreased or remained unchanged in 21 and increased in 26 of these 47 cases. Cancer detection rate in the former group was 52.4% (11\/21), while it was 7.7% (2\/26) in the latter (p = 0.002). There were 38 patients with increased PSA levels after antibiotics. The f\/t PSA ratios decreased or remained unchanged in 20 and increased in 18 of these 38 cases. Cancer detection rates were 55% (11\/20) in the former and 16.7% (3\/18) in the latter group (p = 0.003). &lt;i&gt;Conclusions:&lt;\/i&gt; The PSA and f\/t PSA levels may change with long-term antibiotic treatment in patients with elevated PSA values. The f\/t PSA ratio rather than total PSA appears to be more helpful in suggesting prostate cancer in these cases.<\/jats:p>","DOI":"10.1159\/000209355","type":"journal-article","created":{"date-parts":[[2009,5,11]],"date-time":"2009-05-11T14:20:03Z","timestamp":1242051603000},"page":"266-269","source":"Crossref","is-referenced-by-count":8,"title":["Do Changes in a High Serum Prostate-Specific Antigen Level and the Free\/Total Prostate-Specific Antigen Ratio after Antibiotic Treatment Rule Out Biopsy and the Suspicion of Cancer?"],"prefix":"10.1159","volume":"82","author":[{"given":"Ayhan","family":"Dirim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Ilteris","family":"Tekin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eser","family":"Koyluoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet Ibrahim","family":"Oguzulgen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levent","family":"Peskircioglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakan","family":"Ozkardes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,5,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.270.8.948"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ju.0000162017.24965.2b"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.eururo.2004.08.003"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-199805000-00050"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0045%281996%297%2B%3C48%3A%3AAID-PROS7%3E3.0.CO%3B2-F"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-4295%2899%2900185-5"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.279.19.1542"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-5347%2801%2963570-5"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/209355","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/209355","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:40:36Z","timestamp":1745448036000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000209355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":8,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2009,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000209355","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"type":"print","value":"0042-1138"},{"type":"electronic","value":"1423-0399"}],"subject":[],"published":{"date-parts":[[2009]]}}}