{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T14:40:43Z","timestamp":1759588843663,"version":"3.40.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2009]]},"abstract":"<i>Introduction:<\/i> We retrospectively compared 6- and 12-core prostate biopsies in Taiwanese men and evaluated the impact of prostate volume (PV), prostate-specific antigen (PSA), and PSA density (PSAD) on the prostate cancer detection rate (PCDR). <i>Patients and Methods:<\/i> 1,086 consecutive patients with a total PSA of 4.1\u201320.0 ng\/ml and\/or abnormal digital rectal examination undergoing first-time transrectal ultrasound-guided biopsy were included. Group I patients (n = 562) underwent sextant biopsy and group II patients (n = 524) underwent sextant biopsy with an extra three lateral cores on both sides. The patients were further stratified into subgroups according to PV (cut-off: 35 ml), PSA (cut-off: 10.0 ng\/ml), and PSAD (cut-off: 0.2). <i>Results:<\/i> Prostate cancer was diagnosed in 228\/1,086 (21.0%) patients. The PCDR was higher in group II (23.7%) than group I (18.5%). 12-Core biopsy yielded a significantly higher PCDR than 6-core biopsies in patients with PV >35 ml, PSA 4.1\u201310.0 ng\/ml, PSAD \u22640.20, but not in patients with PV \u226435 ml, PSA 10.1\u201320.0 ng\/ml, PSAD >0.20. <i>Conclusions:<\/i> 12-Core biopsy yielded a significantly higher PCDR in Taiwanese men with a total PSA of 4.1\u201320.0 ng\/ml, especially in patients with PSA 4.1\u201310.0 ng\/ml, PSAD \u22640.20, and PV >35 ml.<\/jats:p>","DOI":"10.1159\/000209356","type":"journal-article","created":{"date-parts":[[2009,5,11]],"date-time":"2009-05-11T14:20:03Z","timestamp":1242051603000},"page":"270-275","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of 6- and 12-Core Prostate Biopsy in Taiwanese Men: Impact of Total Prostate-Specific Antigen, Prostate-Specific Antigen Density and Prostate Volume on Prostate Cancer Detection"],"prefix":"10.1159","volume":"82","author":[{"given":"I-Ni","family":"Chiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang-Jen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeong-Shiau","family":"Pu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuo-How","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Jen","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao-Yaun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,5,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.eururo.2005.08.008"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.eururo.2006.01.040"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.eururo.2007.02.062"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1080%2F13685530412331284687"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1080%2F13557850120068432"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2605.2000.00012.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-4295%2898%2900066-1"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-4295%2801%2900979-7"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.eururo.2007.03.031"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.eururo.2005.08.013"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.4103%2F0019-509X.17060"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1442-2042.2005.01058.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10147-003-0361-5"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000020192"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00185070"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-5347%2805%2965851-X"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/209356","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/209356","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:40:37Z","timestamp":1745448037000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000209356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":16,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2009,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000209356","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"type":"print","value":"0042-1138"},{"type":"electronic","value":"1423-0399"}],"subject":[],"published":{"date-parts":[[2009]]}}}