{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:07:41Z","timestamp":1759032461939,"version":"3.40.4"},"reference-count":20,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Aims:&lt;\/i&gt; We intended to investigate the relative genetic contribution in wavefront aberrations using a sub-group of twins recruited in the Genes in Myopia twin study, and subsequently provide direction for future studies into the aetiology of mono-chromatic aberrations. To our knowledge, the Genes in Myopia twin study is the first study to explore the role of genetic factors in both lower- and higher-order aberrations in a Caucasian population. &lt;i&gt;Methods:&lt;\/i&gt; Each individual completed a general questionnaire and underwent a comprehensive eye examination. Higher-order wavefront aberrations were calculated with Zernike coefficients up to the fourth order. &lt;i&gt;Results:&lt;\/i&gt; A total of 46 twin pairs with a mean age of 65.3 years were included in the analysis. Monozygotic intra-pair correlations were significantly higher compared to those in dizygotic twin pairs for defocus aberrations (p &lt; 0.05). A trend for a genetic component was identified for higher-order aberrations. &lt;i&gt;Conclusion:&lt;\/i&gt; Genetic studies into refraction typically explore the genetic effects of lower-order aberrations such as myopia and hypermetropia; however, there is little to no research into the genetic basis of higher-order aberrations. The Genes in Myopia twin study indicates a potential genetic role for higher-order aberrations and provides useful insights into the aetiology of refractive error.<\/jats:p>","DOI":"10.1159\/000209667","type":"journal-article","created":{"date-parts":[[2009,3,27]],"date-time":"2009-03-27T09:30:57Z","timestamp":1238146257000},"page":"142-147","source":"Crossref","is-referenced-by-count":2,"title":["Role of Genetic Factors in Lower- and Higher-Order Aberrations \u2013 The Genes in Myopia Twin Study"],"prefix":"10.1159","volume":"41","author":[{"given":"M.","family":"Dirani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Chamberlain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.A.","family":"Couper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.H.","family":"Guymer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.N.","family":"Baird","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,3,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1186%2F1471-2415-4-1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ajo.2004.01.051"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1364%2FJOSAA.22.001732"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clae.2005.02.003"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1364%2FJOSAA.19.002329"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1442-9071.2005.00994.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3346%2Fjkms.2005.20.5.860"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clae.2004.12.001"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2F01.opx.0000171335.57812.a2"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1375%2Ftwin.9.4.566"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00439-006-0312-0"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001%2Farchopht.125.1.38"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1080%2F09286580500281222"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097%2F01.opx.0000187847.48093.55"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jcrs.2004.10.068"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097%2F00006324-199312000-00005"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01065819"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02361159"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1469-1809.1975.tb00124.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01067795"}],"container-title":["Ophthalmic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/209667","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/209667","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:43:13Z","timestamp":1745448193000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000209667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":20,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2009,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000209667","archive":["Portico"],"relation":{},"ISSN":["0030-3747","1423-0259"],"issn-type":[{"type":"print","value":"0030-3747"},{"type":"electronic","value":"1423-0259"}],"subject":[],"published":{"date-parts":[[2009]]}}}