{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:00:14Z","timestamp":1761919214994,"version":"3.40.4"},"reference-count":32,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>Common variable immunodeficiency (CVID) is a heterogeneous group of disorders, characterized by hypogammaglobulinemia and an increased susceptibility to recurrent infections, autoimmunity and cancers. There are some conflicting results regarding the cytokine profile of CVID patients. While cytokine production could be associated with gene polymorphism, genetic profiles of a number of cytokines were analyzed in this study. The allele and genotype frequencies of the polymorphic genes coding for interleukin (IL)-2, IL-12, interferon-\u03b3 and transforming growth factor (TGF)-\u03b2 were investigated in 30 patients with CVID in comparison with 140 controls. The genotype TGF-\u03b2 CG at position +915 was significantly overrepresented in the patient group, while the frequencies of the genotypes TGF-\u03b2 TT at +869 and GG at +915 were significantly decreased in the patient group in comparison with controls. TGF-\u03b2 TC and IL-2 GT were the most frequent haplotypes in the patients, whereas the TGF-\u03b2 TG haplotype was significantly decreased in the patient group. The allele and genotype frequencies of interferon-\u03b3 at position UTR +5644 and also IL-12 at position \u20131188 were similar in patients and controls. Cytokine single nucleotide polymorphisms could play a role in the pathophysiology of CVID. Considering the significantly lower frequency of the high production haplotype (TG) and the higher frequency of the low production halplotype (TC) of TGF-\u03b2, low production of this cytokine is expected in some CVID patients.<\/jats:p>","DOI":"10.1159\/000210374","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T14:14:27Z","timestamp":1238681667000},"page":"1-7","source":"Crossref","is-referenced-by-count":20,"title":["Cytokine Gene Polymorphisms in Common Variable 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