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Karger AG","issue":"1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Surg Res"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>This study was designed to determine the effects of intraperitoneally or orally administered N-acetylcysteine (NAC) on wound healing following resection and anastomosis of a colon segment with ischemia\/reperfusion injury. Forty female Spraque-Dawley rats were randomly allocated to one of four groups containing 10 rats each: (1) normal resection plus anastomosis; (2) ischemia\/reperfusion plus resection plus anastomosis; (3) ischemia\/reperfusion plus resection plus anastomosis plus intraperitoneal NAC; (4) ischemia\/reperfusion plus resection plus anastomosis plus oral NAC. Group comparison showed that the anastomosis bursting pressure was significantly higher in group 3 than in the other groups. The mean tissue hydroxyproline concentration in the anastomotic tissue was significantly lower in group 2 than in the other groups. The collagen deposition was significantly increased on day 7 in groups 3 and 4 compared to the other groups. In conclusion, this study demonstrates that NAC significantly prevents the effects of reperfusion injury on colonic anastomoses in a rat model.<\/jats:p>","DOI":"10.1159\/000210673","type":"journal-article","created":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T10:13:46Z","timestamp":1239012826000},"page":"8-12","source":"Crossref","is-referenced-by-count":13,"title":["N-Acetylcysteine Prevents Deleterious Effects of Ischemia\/Reperfusion Injury on Healing of Colonic Anastomosis in Rats"],"prefix":"10.1159","volume":"43","author":[{"given":"B.","family":"Kabali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Girgin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Gedik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Ozturk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Kale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Buyukbayram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,4,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.281.6237.411"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0039-6109%2805%2970568-5"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9610%2805%2981153-5"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1067%2Fmsy.2000.107414"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3468%2898%2990369-4"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9610%2898%2900198-6"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2168.2002.02279.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jss.2006.10.030"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2Fbjs.1800810504"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1006%2Fjsre.2001.6103"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2F0891-5849%2889%2990066-X"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002%2Fjcb.240531040"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2165%2F00003088-199120020-00004"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1021%2Fac60205a053"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00268-001-0256-4"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007%2Fs002680010170"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02134183"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01645157"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097%2F00003246-199309000-00023"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1006%2Fjsre.1994.1203"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2F0006-2952%2891%2990674-T"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2FS0891-5849%2897%2900137-8"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2F0163-7258%2888%2990027-7"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2F0006-2952%2890%2990515-M"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02253360"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2FS1357-2725%2896%2900134-3"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1159%2F000049699"}],"container-title":["European Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/210673","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/210673","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:52:19Z","timestamp":1745448739000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000210673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2009,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000210673","archive":["Portico"],"relation":{},"ISSN":["0014-312X","1421-9921"],"issn-type":[{"value":"0014-312X","type":"print"},{"value":"1421-9921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}