{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:13:22Z","timestamp":1777947202674,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,3,31]],"date-time":"2009-03-31T00:00:00Z","timestamp":1238457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,3,31]],"date-time":"2009-03-31T00:00:00Z","timestamp":1238457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Pharmacol"],"abstract":"<jats:p>The relevance of salicylic acid in dithranol creams was evaluated in a double-blind study. Patients with chronic plaque psoriasis were treated using a short-contact schedule for dithranol on an outpatient basis. A left-right comparison was carried out between sites treated with either dithranol with 2 % salicylic acid (D+S) or dithranol in the same base without salicylic acid (D-S). Clinical results were evaluated once a week using the psoriasis area severity index. In order to quantify the improvement, flow cytometric measurements were done using the monoclonal antibody K&lt;sub&gt;s&lt;\/sub&gt;8.12, recognizing keratin 16 in normal and lesional epidermis. Simultaneously, relative DNA content was quantified which previously was described as a useful method to monitor a therapeutic effect. Both PASI scores and K&lt;sub&gt;s&lt;\/sub&gt;8.12 binding decreased after 6 weeks treatment with D+S and D-S. However, percentages of cells in SG&lt;sub&gt;2&lt;\/sub&gt;M phases did not show a significant change. No significant difference was observed between sites treated with either D+S or D-S. Therefore we conclude that the addition of salicylic acid in a concentration of 2 % does not enhance the efficacy of dithranol creams and we confirm that K&lt;sub&gt;s&lt;\/sub&gt;8.12 is a useful quantitative marker for therapeutic efficacy.<\/jats:p>","DOI":"10.1159\/000210784","type":"journal-article","created":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T06:13:46Z","timestamp":1238998426000},"page":"259-264","source":"Crossref","is-referenced-by-count":13,"title":["The Relevance of Salicylic Acid in the Treatment of Plaque Psoriasis with Dithranol Creams"],"prefix":"10.1159","author":[{"given":"S.","family":"de Mare","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Calis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"den Hartog","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.E.J.","family":"van Erp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.C.M.","family":"van de Kerkhof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,3,31]]},"container-title":["Skin Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/210784","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000210784","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T22:35:03Z","timestamp":1777761303000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000210784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,31]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000210784","archive":["Portico"],"relation":{},"ISSN":["1011-0283","2571-7162"],"issn-type":[{"value":"1011-0283","type":"print"},{"value":"2571-7162","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,31]]}}}