{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:13:26Z","timestamp":1777947206514,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,3,31]],"date-time":"2009-03-31T00:00:00Z","timestamp":1238457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,3,31]],"date-time":"2009-03-31T00:00:00Z","timestamp":1238457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Pharmacol"],"abstract":"<jats:p>Transforming growth factor \u0391 (TGF\u0391) is a keratinocyte-growth-stimulating factor which may have a role in epidermal hyperproliferation, psoriasis, and wound healing. Since increased epidermal proliferation occurs in response to UV radiation, we have measured the amount of TGF\u0391 in exudates from normal and UVB-irradiated human skin. Cutaneous exudates were obtained using the skin chamber abrasion technique from one side of the back of volunteers (n = 10) with normal skin (collected following skin contact times of 2 and 30 min). Exudates were similarly obtained from the contralateral side of the back at sites irradiated 2 h previously with 3 \u00d7 the minimum erythemal dose UVB. Levels of TGF\u0391 were measured by radioimmunoassay. Normal human skin released TGF\u0391 immediately after abrasion: unirradiated, 63 \u00b1 18 ng\/ml; irradiated, 89 \u00b1 15 ng\/ml. Levels of TGF\u0391 increased within 30 min to 110 \u00b1 14 ng\/ml in unirradiated skin and to 190 \u00b1 17 ng\/ml in irradiated skin. Irradiated sites at 30-min time points were significantly higher (p &lt; 0.05) than all other samples. The presence of releasable TGF\u0391 in normal skin suggests a role for TGF\u0391 in wound repair mechanisms.<\/jats:p>","DOI":"10.1159\/000210925","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T10:14:27Z","timestamp":1238667267000},"page":"61-64","source":"Crossref","is-referenced-by-count":22,"title":["Transforming Growth Factor \u03b1: In vivo Release by Normal Human Skin following UV Irradiation and Abrasion"],"prefix":"10.1159","author":[{"given":"Leslie C.","family":"James","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison M.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry A.","family":"Wheeler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilliam M.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline M.","family":"Dowd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malcolm W.","family":"Greaves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,3,31]]},"container-title":["Skin Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/210925","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000210925","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T22:36:35Z","timestamp":1777761395000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000210925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,31]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000210925","archive":["Portico"],"relation":{},"ISSN":["1011-0283","2571-7162"],"issn-type":[{"value":"1011-0283","type":"print"},{"value":"2571-7162","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,31]]}}}