{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T23:00:28Z","timestamp":1771455628588,"version":"3.50.1"},"reference-count":30,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Gastroesophageal reflux disease (GERD) leads to endoscopic and histomorphological changes in the gastroesophageal (GE) mucosa. &lt;i&gt;Aims:&lt;\/i&gt; To evaluate the expression of the cytokines interleukin-1\u03b2 (IL-1\u03b2) and interleukin-8 (IL-8) in the GE mucosa in GERD patients and controls and to correlate the cytokine expression with the histomorphological parameters. &lt;i&gt;Methods:&lt;\/i&gt; One hundred and fifteen patients, 48 with erosive reflux disease (ERD) and 41 with non-erosive reflux disease (NERD) with typical GERD-related symptoms, and 26 controls were included. Endoscopic and histological characterization of esophagitis was performed according to the Los Angeles and Ismeil-Beigi\/Vieth criteria, respectively. Mucosal gene expression levels of IL-1\u03b2 and IL-8 were analyzed by real-time RT-PCR. &lt;i&gt;Results:&lt;\/i&gt; ERD and NERD patients revealed significant higher levels of IL-1\u03b2 and IL-8 transcript levels in the cardia and esophageal mucosa than controls. The esophageal mucosa revealed elevated IL-8 (2.5- and 8.7-fold) and IL-1\u03b2 (4.1- and 7.8-fold) transcript levels in NERD and ERD, respectively. Histological analysis demonstrated a stepwise increase of dilatation of intercellular spaces and the degree of basal cell hyperplasia from controls, NERD towards ERD. Gene expression levels of both cytokines correlated with histology. &lt;i&gt;Conclusions:&lt;\/i&gt; ERD and NERD are associated with an induction of the proinflammatory cytokines IL-1\u03b2 and IL-8 that correlates with histomorphological changes in esophageal mucosa.<\/jats:p>","DOI":"10.1159\/000211714","type":"journal-article","created":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T10:13:46Z","timestamp":1239012826000},"page":"186-195","source":"Crossref","is-referenced-by-count":47,"title":["Interleukin-1Beta and Interleukin-8 Expression Correlate with the Histomorphological Changes in Esophageal Mucosa of Patients with Erosive and Non-Erosive Reflux Disease"],"prefix":"10.1159","volume":"79","author":[{"given":"Klaus","family":"M\u00f6nkem\u00fcller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Wex","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doerthe","family":"Kuester","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia 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