{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:14:06Z","timestamp":1780582446899,"version":"3.54.1"},"reference-count":29,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Surg"],"published-print":{"date-parts":[[2009]]},"abstract":"<i>Rationale\/Hypothesis:<\/i> Forkhead box protein P1 (FOXP1) is one member of the forkhead box protein P (FOXP) subfamily, which are transcription factors that mediate signaling and affect gene regulation, and elevated expression of FOXP1 has been reported to correlate with poor prognosis of diffuse large B-cell lymphoma (DLBCL). Recently, it was also found that <i>FOXP1<\/i> expression occurs in mucosa-associated lymphoid tissue (MALT) lymphomas. <i>Objective:<\/i> FOXP1 expression and its relationship to morphology and prognosis in a series of 43 gastric MALT lymphomas were investigated retrospectively. <i>Findings:<\/i> The FOXP1 nuclear expression (44.2%, 19\/43) of tumors between mono- and polymorphic histology (4 of 26 [15.4%] vs. 15 of 17 [88.2%]) was significantly different (p < 0.001). All 14 relapsed tumors after operation featured strong nuclear FOXP1 positivity. A significantly shorter cumulative 10-year survival (52.6%,10\/19) was found in high FOXP1 expression patients, compared with patients with negative expression (83.3%, 20\/24) (p < 0.01). Also, the cumulative 10-year survival rate (30.8%, 4\/13) for stage IIE+IV was significantly shorter than that (83.3%, 25\/30) in stage I+II (p < 0.01). Moreover, high FOXP1 expression and advanced stage IIE+IV were independent prognostic factors in multivariate Cox regression analysis. <i>Conclusions:<\/i> Our results show that FOXP1 expression is correlated with morphic histology, and FOXP1 and clinical staging appear to be independent prognostic factors in gastric MALT lymphomas.<\/jats:p>","DOI":"10.1159\/000212058","type":"journal-article","created":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T11:43:08Z","timestamp":1239190988000},"page":"156-162","source":"Crossref","is-referenced-by-count":26,"title":["FOXP1 Expression Predicts Polymorphic Histology and Poor Prognosis in Gastric Mucosa-Associated Lymphoid Tissue Lymphomas"],"prefix":"10.1159","volume":"26","author":[{"given":"Shao-liang","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-ling","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-qiang","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-lin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,4,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2002-09-2963"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2002-10-3236"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0092-8674%2800%2980957-5"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.1090769"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0092-8674%2801%2900189-1"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS1074-7613%2803%2900293-0"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1006%2Fdbio.2002.0780"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093%2Fmolbev%2Fmsn091"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1086%2F522237"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038%2F83784"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007%2Fs002510100358"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI11679"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038%2F35097076"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038%2F83713"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2003-05-1545"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2006.05.6150"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038%2Fnri953"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002%2Fgcc.2870110203"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2004-03-1209"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002%2Fgcc.20278"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2004.10.087"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2005-01-0004"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.beha.2004.08.003"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2F0140-6736%2891%2992035-Z"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016%2FS0065-230X%2808%2960096-2"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.leu.2400718"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2004-03-1209"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.leu.2404517"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1517%2F14728222.9.5.1045"}],"container-title":["Digestive Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/212058","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/212058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T23:08:00Z","timestamp":1745449680000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000212058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":29,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2009,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000212058","archive":["Portico"],"relation":{},"ISSN":["0253-4886","1421-9883"],"issn-type":[{"value":"0253-4886","type":"print"},{"value":"1421-9883","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}