{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T10:22:56Z","timestamp":1768299776699,"version":"3.49.0"},"reference-count":14,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; To report 2 cases of large subretinal haemorrhage in 2 patients with age-related macular degeneration when the intravitreal injections were changed from bevacizumab (Avastin) to ranibizumab (Lucentis). &lt;i&gt;Methods:&lt;\/i&gt; Both patients were treated initially with intravitreal bevacizumab 1.25 mg for 4 months (4 injections) and then switched to 0.5 mg ranibizumab which continued for another 6 months. Best-corrected visual acuity measurements, slit-lamp examination, contact lens biomicroscopy, optical coherence tomography and fluorescein angiography were performed at baseline examination and every month. &lt;i&gt;Results:&lt;\/i&gt; Both patients showed initial improvement when treated with intravitreal bevacizumab followed by deterioration and development of a large subretinal haemorrhage when changing to intravitreal ranibizumab. &lt;i&gt;Conclusions:&lt;\/i&gt; There is not enough experience switching from one anti-vascular-endothelial-growth-factor agent to another. A prospective study with large series of patients and controls may be necessary in order to determine whether it is safe enough to change from one medication to another.<\/jats:p>","DOI":"10.1159\/000213644","type":"journal-article","created":{"date-parts":[[2009,4,22]],"date-time":"2009-04-22T14:40:22Z","timestamp":1240411222000},"page":"279-282","source":"Crossref","is-referenced-by-count":16,"title":["Large Subretinal Haemorrhage following Change from Intravitreal Bevacizumab to Ranibizumab"],"prefix":"10.1159","volume":"223","author":[{"given":"Dimitrios A.","family":"Karagiannis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panagiotis","family":"Mitropoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis D.","family":"Ladas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,4,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0039-6257%2803%2900030-4"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa062655"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ophtha.2005.11.019"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097%2F01.iae.0000225766.75009.3a"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ajo.2007.09.031"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa054481"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ajo.2007.10.004"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1001%2Farchopht.125.11.1460"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2FIAE.0b013e31813c68b7"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ajo.2006.11.047"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159%2F000027400"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ajo.2007.07.034"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ophtha.2007.09.012"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097%2FIAE.0b013e318134eecd"}],"container-title":["Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/213644","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/213644","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:15:08Z","timestamp":1745446508000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000213644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":14,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2009,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000213644","archive":["Portico"],"relation":{},"ISSN":["0030-3755","1423-0267"],"issn-type":[{"value":"0030-3755","type":"print"},{"value":"1423-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}