{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:04:12Z","timestamp":1790643852709,"version":"4.1.0"},"reference-count":12,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2009,4,23]],"date-time":"2009-04-23T00:00:00Z","timestamp":1240444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,4,23]],"date-time":"2009-04-23T00:00:00Z","timestamp":1240444800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<i>Background\/Aims:<\/i> We previously found increased urinary protein excretion, glomerular filtration rate (GFR) and blood pressure in a retrospective analysis of patients with previous nephropathia epidemica (NE). Here, we evaluated the long-term outcome after NE in a prospectively recruited patient group. <i>Methods:<\/i> Proteinuria, GFR and ambulatory 24-hour blood pressure were assessed 4\u20137 years (mean 6) after acute NE in 37 patients, and these values were compared to those from 38 seronegative controls. <i>Results:<\/i> Six years after NE, the prevalence of elevated urinary \u03b1<sub>1<\/sub>-microglobulin excretion was higher in the patients than controls (9\/35 vs. 1\/38; p = 0.005). The patients also had higher urinary protein excretion (0.17 \u00b1 0.05 vs. 0.14 \u00b1 0.04 g\/day; p = 0.006), GFR (119 \u00b1 19 vs. 109 \u00b1 14 ml\/min\/1.73 m<sup>2<\/sup>; p = 0.016) and mean systolic (123 \u00b1 11 vs. 117 \u00b1 9 mm Hg; p = 0.012), nighttime systolic (109 \u00b1 11 vs. 100 \u00b1 9 mm Hg; p = 0.001) and nighttime diastolic blood pressure (70 \u00b1 7 vs. 66 \u00b1 7 mm Hg; p = 0.035) than the controls. <i>Conclusions:<\/i> These results confirm our previous findings of a higher prevalence of tubular proteinuria and increased urinary protein excretion, GFR and systolic blood pressure 6 years after acute NE.<\/jats:p>","DOI":"10.1159\/000213899","type":"journal-article","created":{"date-parts":[[2009,4,22]],"date-time":"2009-04-22T14:40:22Z","timestamp":1240411222000},"page":"c115-c120","source":"Crossref","is-referenced-by-count":31,"title":["Tubular Proteinuria and Glomerular Filtration 6 Years after Puumala Hantavirus-Induced Acute Interstitial Nephritis"],"prefix":"10.1159","volume":"112","author":[{"given":"Marja H.","family":"Miettinen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satu M.","family":"M\u00e4kel\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilpo O.","family":"Ala-Houhala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heini S.","family":"Huhtala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiit","family":"K\u00f6\u00f6bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti I.","family":"Vaheri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amos I.","family":"Pasternack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilkka H.","family":"P\u00f6rsti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jukka T.","family":"Mustonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,4,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS1473-3099%2803%2900774-6"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2005050561"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3109%2F00365549409008583"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1080%2F003655400750045204"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2000.00332.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ki.5000334"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00125-006-0393-2"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2362.2005.01497.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2F17.2.246"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1987.50"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ajkd.2003.12.026"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ki.5000320"}],"container-title":["Nephron Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/213899","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/213899","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:17:45Z","timestamp":1745446665000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000213899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,23]]},"references-count":12,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2009,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000213899","archive":["Portico"],"relation":{},"ISSN":["1660-2110"],"issn-type":[{"value":"1660-2110","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,23]]}}}