{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:21:34Z","timestamp":1777929694691,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,4,15]],"date-time":"2009-04-15T00:00:00Z","timestamp":1239753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,4,15]],"date-time":"2009-04-15T00:00:00Z","timestamp":1239753600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Onkologie"],"abstract":"<jats:p>Bei den gastrointestinalen Karzinomen gibt es zur Zeit keine palliative Standardtherapie. Fluorouracil war lange der einzige wirksa-me Stoff, von dem Remissionsraten von 0%-80% berichtet wurden. In gr\u00f6\u00dferen Serien liegen diese jedoch alle um 20%, ohne da\u00df eine Lebensverl\u00e4ngerung bei den Patienten mit Remissionen nachgewie-sen werden konnte. Trotz 20j\u00e4hrigen Gebrauchs ist aber die optima-le Dosierung wie auch zeitliche Gabe bei Fluorouracil noch nicht ge-funden. Durch Kombinationen von Fluorouracil mit anderen Medi-kamenten (Mitomycin C und\/oder Adriamycin beim Magenkarzinom, Methyl-CCNU beim Kolorektalkarzinom) wurden erstmals die Remissionsraten verbessert und nun auch das \u00dcberleben bei den Patienten mit Remissionen verl\u00e4ngert. Die Ergebnisse der adjuvan-ten Chemotherapie sind widerspr\u00fcchlich, eine routinem\u00e4\u00dfige Anwendung ist derzeit nicht empfehlenswert. Adjuvante wie auch palliative Chemotherapie ist mittels klinischer, kontrollierter Untersu-chungen weiterhin zu verbessern.<\/jats:p>","DOI":"10.1159\/000213964","type":"journal-article","created":{"date-parts":[[2009,4,20]],"date-time":"2009-04-20T11:36:39Z","timestamp":1240227399000},"page":"248-256","source":"Crossref","is-referenced-by-count":3,"title":["Chemotherapie gastrointestinaler Tumoren (Literatur\u00fcbersicht)"],"prefix":"10.1159","author":[{"given":"A.C.","family":"Mayr","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,4,15]]},"container-title":["Onkologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/213964","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000213964","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:48:34Z","timestamp":1777679314000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000213964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,15]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000213964","archive":["Portico"],"relation":{},"ISSN":["0378-584X","1423-0240"],"issn-type":[{"value":"0378-584X","type":"print"},{"value":"1423-0240","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,15]]}}}