{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T07:13:32Z","timestamp":1773558812550,"version":"3.50.1"},"reference-count":20,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2009]]},"abstract":"<i>Background:<\/i> We compared the in vitro activities of tigecycline with those of other agents against 97 <i>Streptococcus pneumoniae, <\/i>140 <i>Haemophilus influenzae<\/i> and54 <i>Moraxella catarrhalis<\/i> strains isolated in two large university hospitals in Istanbul. <i>Methods:<\/i> For analysis, the agar dilution method was used. <i>Results:<\/i> For <i>S. pneumoniae<\/i> isolates, 32% were not susceptible to penicillin (28.9% intermediate and 3.1% resistant). Cefotaxime, telithromycin, moxifloxacin and linezolid were fully active. Tigecycline had a 90% minimum inhibitory concentration (MIC<sub>90<\/sub>) of 0.12 \u03bcg\/ml. For <i>H. influenzae,<\/i> 8.57% were not susceptible to ampicillin, among which 8 possessed \u03b2-lactamase (5.7%). Four (2.87%) <i>H. influenzae<\/i> isolates with \u03b2-lactamase-negative and ampicillin-resistant phenotype were found. All isolates were susceptible to ceftriaxone, azithromycin, ciprofloxacin, levofloxacin and moxifloxacin. MIC<sub>90<\/sub> for tigecycline was 0.5 \u03bcg\/ml. Of 54 <i>M. catarrhalis<\/i> isolates, 88.9% possessed \u03b2-lactamase. Tigecycline and fluoroquinolones were highly active (MIC<sub>90<\/sub> \u22640.12 \u03bcg\/ml). <i>Conclusions:<\/i> Linezolid, telithromycin, newer fluoroquinolones and tigecycline all have excellent in vitro activities against the 3 respiratory pathogens.<\/jats:p>","DOI":"10.1159\/000214144","type":"journal-article","created":{"date-parts":[[2009,4,22]],"date-time":"2009-04-22T14:40:22Z","timestamp":1240411222000},"page":"161-167","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of in vitro Activities of Tigecycline with Other Antimicrobial Agents against <i>Streptococcus pneumoniae,<\/i><i>Haemophilus influenzae<\/i> and <i>Moraxella catarrhalis <\/i>in Two University Hospitals in Istanbul, Turkey"],"prefix":"10.1159","volume":"55","author":[{"given":"Nevriye","family":"Gonullu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fadimana","family":"Catal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omer","family":"Kucukbasmaci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinem","family":"Ozdemir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muzeyyen Mamal","family":"Torun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahmiye","family":"Berkiten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,4,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jinf.2007.04.006"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159%2F000167788"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.diagmicrobio.2004.03.002"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1128%2FJCM.02351-06"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1469-0961.2004.00932.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1469-0691.2001.00344.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0924-8579%2802%2900003-1"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0924-8579%2803%2900150-X"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0924-8579%2803%2900242-5"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1469-0691.2003.00780.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093%2Fjac%2Fdkm232"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.diagmicrobio.2006.07.005"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000112415"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000118660"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093%2Fjac%2Fdki167"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijantimicag.2003.05.013"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093%2Fjac%2Fdkn083"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093%2Fjac%2Fdkh178"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1469-0691.2008.02063.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1590%2FS1413-86702005000500001"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/214144","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/214144","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:19:24Z","timestamp":1745446764000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000214144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":20,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2009,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000214144","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"value":"0009-3157","type":"print"},{"value":"1421-9794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}