{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T21:07:45Z","timestamp":1775855265467,"version":"3.50.1"},"reference-count":8,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Angiographic studies suggest that acute vasospasm within 48 h of aneurysmal subarachnoid hemorrhage (SAH) predicts symptomatic vasospasm. However, the value of transcranial Doppler within 48 h of SAH is unknown. &lt;i&gt;Methods:&lt;\/i&gt; We analyzed 199 patients who had at least 1 middle cerebral artery (MCA) transcranial Doppler examination within 48 h of SAH onset. Abnormal MCA mean blood flow velocity (mBFV) was defined as &gt;90 cm\/s. Delayed cerebral ischemia (DCI) was defined as clinical deterioration or radiological evidence of infarction due to vasospasm. &lt;i&gt;Results:&lt;\/i&gt; Seventy-six patients (38%) had an elevation of MCA mBFV &gt;90 cm\/s within 48 h of SAH onset. The predictors of elevated mBFV included younger age (OR = 0.97 per year of age, p = 0.002), admission angiographic vasospasm (OR = 5.4, p = 0.009) and elevated white blood cell count (OR = 1.1 per 1,000 white blood cells, p = 0.003). Patients with elevated mBFV were more likely to experience a 10 cm\/s fall in velocity at the first follow-up than those with normal baseline velocities (24 vs. 10%, p &lt; 0.01), suggestive of resolving spasm. DCI developed in 19% of the patients. An elevated admission mBFV &gt;90 cm\/s during the first 48 h (adjusted OR = 2.7, p = 0.007) and a poor clinical grade (Hunt-Hess score 4 or 5, OR = 3.2, p = 0.002) were associated with a significant increase in the risk of DCI. &lt;i&gt;Conclusion:&lt;\/i&gt; Early elevations of mBFV correlate with acute angiographic vasospasm and are associated with a significantly increased risk of DCI. Transcranial Doppler ultrasound may be an early useful tool to identify patients at higher risk to develop DCI after SAH.<\/jats:p>","DOI":"10.1159\/000214222","type":"journal-article","created":{"date-parts":[[2009,4,24]],"date-time":"2009-04-24T13:41:27Z","timestamp":1240580487000},"page":"579-584","source":"Crossref","is-referenced-by-count":28,"title":["Transcranial Doppler Ultrasound in the Acute Phase of Aneurysmal Subarachnoid Hemorrhage"],"prefix":"10.1159","volume":"27","author":[{"given":"Emmanuel","family":"Carrera","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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Sander","family":"Connolly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neeraj","family":"Badjatia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan A.","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,4,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2807%2960153-6"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161%2Fhs1001.097108"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000144654.79393.cf"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097%2F00006123-199905000-00017"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00134-003-1780-5"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2F0301-5629%2889%2990125-7"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097%2F00002060-199611000-00002"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1227%2F01.NEU.0000218821.34014.1B"}],"container-title":["Cerebrovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/214222","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/214222","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:20:33Z","timestamp":1745446833000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000214222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":8,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2009,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000214222","archive":["Portico"],"relation":{},"ISSN":["1015-9770","1421-9786"],"issn-type":[{"value":"1015-9770","type":"print"},{"value":"1421-9786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}