{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:58:12Z","timestamp":1777946292311,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,4,16]],"date-time":"2009-04-16T00:00:00Z","timestamp":1239840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,4,16]],"date-time":"2009-04-16T00:00:00Z","timestamp":1239840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemostasis"],"abstract":"<jats:p>Cryoprecipitate was infused into pigs with severe von Willebrand\u2019s disease, and the bleeding time was corrected when the plasmatic level of VIII R:AG (WF) was above 30 U\/dl. The VIII R:AG (WF) was not completely recovered but none was found in the plasma or endothelial cells. A new method for measuring the bleeding time is described -the ratio bleeding time. These results in pigs are compared with the reported results in humans.<\/jats:p>","DOI":"10.1159\/000214377","type":"journal-article","created":{"date-parts":[[2009,4,16]],"date-time":"2009-04-16T11:28:57Z","timestamp":1239881337000},"page":"352-365","source":"Crossref","is-referenced-by-count":0,"title":["Hemostatic Effect of Transfused Willebrand Factor in Porcine von Willebrand\u2019s Disease"],"prefix":"10.1159","author":[{"given":"E.J.W.","family":"Bowie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.N.","family":"Fass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.A.","family":"Owen, Jr.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,4,16]]},"container-title":["Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/214377","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000214377","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T16:27:26Z","timestamp":1777739246000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000214377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,16]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000214377","archive":["Portico"],"relation":{},"ISSN":["0301-0147","1423-0038"],"issn-type":[{"value":"0301-0147","type":"print"},{"value":"1423-0038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,16]]}}}