{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:21:30Z","timestamp":1777929690088,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,4,17]],"date-time":"2009-04-17T00:00:00Z","timestamp":1239926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,4,17]],"date-time":"2009-04-17T00:00:00Z","timestamp":1239926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Onkologie"],"abstract":"<jats:p>Acht zytostatische Medikamente wurden auf ihre Eigenschaft als Proteaseinhibitoren auf f\u00fcnf Proteasen getestet. Zus\u00e4tzlich wurde die koUagenolytische Aktivit\u00e4t eines menschlichen Rhabdomyosarkoms untersucht, und es wurden Inhibitionsstudien durchgef\u00fchrt. Wir fanden, da\u00df 5-Fluorouracil die koUagenolytische Aktivit\u00e4t klostridialen Ursprungs und des Tumors zu hemmen vermag. Kein anderes Zytostatikum zeigte Hemmwirkung auf die koUagenolytische Aktivit\u00e4t. Die Kollagenolyse des Tumorsystems wurde durch \u00c4thylen-diamin-tetraacetat (EDTA) nicht gehemmt, was den Ursprung des Enzymsystems aus Leukozytenlysosomen unwahrscheinlich macht und darauf schlie\u00dfen l\u00e4\u00dft, da\u00df das hydrolytische Ferment aus dem Tumor selbst stammt. In dieser Arbeit soil die koUagenolytische Aktivit\u00e4t des Tumors beschrieben werden sowie deren Hemmbarkeit durch 5-Fluorouracil, das dadurch einen Einflu\u00df auf das biologische Verhalten des Rhabdomyosarkoms, wie Zellwachstum, Regeneration und den Intermedi\u00e4rstoffwechsel annehmen l\u00e4\u00dft.<\/jats:p>","DOI":"10.1159\/000214454","type":"journal-article","created":{"date-parts":[[2009,4,20]],"date-time":"2009-04-20T11:36:39Z","timestamp":1240227399000},"page":"38-40","source":"Crossref","is-referenced-by-count":0,"title":["5 -Fluorouracil hemmt bakterielle Kollagenase und das kollagenolytische System eines menschlichen Rhabdomyosarkoms"],"prefix":"10.1159","author":[{"given":"G.","family":"Lubec","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St.","family":"Szalay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,4,17]]},"container-title":["Onkologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/214454","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000214454","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:48:45Z","timestamp":1777679325000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000214454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,17]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000214454","archive":["Portico"],"relation":{},"ISSN":["0378-584X","1423-0240"],"issn-type":[{"value":"0378-584X","type":"print"},{"value":"1423-0240","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,17]]}}}