{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:31:59Z","timestamp":1791811919382,"version":"4.3.4"},"reference-count":21,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Nutr Metab"],"published-print":{"date-parts":[[2009]]},"abstract":"<i>Aims:<\/i> The aim of this study was to investigate the antiobesity effect of (\u2013)-epigallocatechin-3-gallate (EGCG) in diet-induced obese mice. <i>Methods:<\/i> Male C57BL\/6J mice were fed on a high-fat diet for 8 weeks to induce obesity. Subsequently they were divided into 3 groups and were maintained on a high-fat control diet or high-fat diets supplemented with 0.2 or 0.5% EGCG (w\/w) for a further 8 weeks. Changes in the expression of genes related to lipid metabolism and fatty acid oxidation were analyzed in white adipose tissue, together with biometric and blood parameters. <i>Results:<\/i> Experimental diets supplemented with EGCG resulted in reduction of body weight and mass of various adipose tissues in a dose-dependent manner. EGCG diet also considerably lowered the levels of plasma triglyceride and liver lipid. In the epididymal white adipose tissue of EGCG diet-fed mice, the mRNA levels of adipogenic genes such as peroxisome proliferator-activated receptor-\u03b3 (PPAR-\u03b3), CCAAT enhancer-binding protein-\u03b1 (C\/EBP-\u03b1), regulatory element-binding protein-1c (SREBP-1c), adipocyte fatty acid-binding protein (aP2), lipoprotein lipase (LPL) and fatty acid synthase (FAS) were significantly decreased. However, the mRNA levels of carnitine palmitoyl transferase-1 (CPT-1) and uncoupling protein 2 (UCP2), as well as lipolytic genes such as hormone sensitive lipase (HSL) and adipose triglyceride lipase (ATGL), were significantly increased. <i>Conclusion:<\/i> These results suggest that green tea EGCG effectively reduces adipose tissue mass and ameliorates plasma lipid profiles in high-fat diet-induced obese mice. These effects might be at least partially mediated via regulation of the expression of multiple genes involved in adipogenesis, lipolysis, \u03b2-oxidation and thermogenesis in white adipose tissue.<\/jats:p>","DOI":"10.1159\/000214834","type":"journal-article","created":{"date-parts":[[2009,4,22]],"date-time":"2009-04-22T14:40:22Z","timestamp":1240411222000},"page":"151-157","source":"Crossref","is-referenced-by-count":184,"title":["Green Tea (\u2013)-Epigallocatechin-3-Gallate Reduces Body Weight with Regulation of Multiple Genes Expression in Adipose Tissue of Diet-Induced Obese Mice"],"prefix":"10.1159","volume":"54","author":[{"given":"Mak-Soon","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong-Tai","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangha","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,4,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F0091-7435%2883%2990244-X"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1080%2F10408399709527797"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1271%2Fbbb.69.2455"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ijo.0802926"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ijo.0802141"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000084178"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jnutbio.2003.08.005"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038%2Foby.2007.176"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1078%2F0944-7113-00078"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0955-2863%2803%2900054-8"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jnutbio.2006.12.005"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1021%2Fjf0006832"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.274.24.17088"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.272.34.21473"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1101%2Fgad.10.9.1096"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097%2F00041433-199706000-00006"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1079%2FPNS19960013"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.1100747"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1432-1033.1997.00001.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038%2F88911"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1017%2FS0007114507864816"}],"container-title":["Annals of Nutrition and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/214834","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/214834","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:26:46Z","timestamp":1745447206000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000214834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":21,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2009,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000214834","archive":["Portico"],"relation":{},"ISSN":["0250-6807","1421-9697"],"issn-type":[{"value":"0250-6807","type":"print"},{"value":"1421-9697","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}